ReviewIndian journal of orthopaedics2025
Efficacy of Autologous Platelet-Rich Plasma for the Treatment of Ankle Sprain: A Systematic Review of Literature with Limited Meta-Analysis.
Review in Indian journal of orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Platelet-rich plasma and hyaluronic acid in the treatment of acute ankle sprains: A review.Biomolecules & biomedicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lateral ankle sprains are common among active individuals and, if not managed properly, can result in recurrent sprains, chronic instability, and post-traumatic ankle osteoarthritis. Standard treatment includes physical therapy and a brief period of rest, followed by early functional rehabilitation. Autologous platelet-rich plasma, which is rich in growth factors, has demonstrated promising healing responses in acute ankle sprains. This systematic review assessed the current evidence regarding the efficacy and adverse events associated with autologous PRP injection in acute ankle sprain injuries. Method: This systematic review adhered to PRISMA guidelines. An electronic search was performed across PubMed, Embase, Scopus, and Cochrane Library using specific keywords. Eligible studies comprised prospective or retrospective comparisons of autologous PRP injection versus control for acute ankle sprain injuries reported in English. Results: Three randomized controlled trials and one prospective comparative study met the inclusion criteria, involving 85 ankle injuries in 84 autologous PRP injection groups and 57 ankle injuries in 56 patients in the control group. Autologous PRP injection provided superior short-term pain relief, functional outcomes, and an earlier return to activity and sports, as well as improved radiological outcomes compared to the control group. However, during the follow-up period, both groups exhibited comparable results in terms of Visual Analog Scale (VAS) scores and functional outcomes, with no reported adverse events. A meta-analysis of limited data for VAS and American Orthopaedic Foot and Ankle Society scores demonstrated comparable outcomes between the two groups. Conclusion: Autologous PRP injection appears to play a beneficial role in acute ankle sprains by reducing pain, expediting return to play, and enhancing function, with no reported adverse events.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.