ArticleFrontiers in oncology2025
Renal dysfunction as a predictor of recurrence and prognosis in colorectal cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study explores the relationship between eGFR and recurrence and prognosis in patients with colorectal cancer (CRC). Methods: Patients first diagnosed with CRC at Zhengzhou People's Hospital between 2018 and 2021 with a median follow-up of 715 days were studied. Demographics, disease characteristics, kidney function were collected. Associations between eGFR and clinical prognosis were assessed using multivariate Cox proportional hazards regression models. The impact of eGFR on the recurrence was evaluated by logistic and Poisson regression models. Odds ratios are reported for associations between eGFR and recurrence and prognosis. Stratified analyses and restricted cubic splines (RCS) were used to evaluate the results between subgroups and nonlinear relation between eGFR and the prognosis and recurrence of patients with CRC. Results: 93 CRC patients completed the study. Poor renal filtration function and impaired urine concentrating ability were found in CRC patients. Multivariate analysis showed that eGFR was an independent predictor of clinical prognosis (eGFR < 90 mL/min OR=4.248, 95% CI [1.061-17.003], Conclusions: CRC patients exhibited kidney dysfunction, and eGFR is identified as an independent predictor of disease recurrence and prognosis.
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