Evidence map›Paper›PMID 40657450›Full record

ArticleCanadian journal of pain = Revue canadienne de la douleur2025

Percutaneous auricular neuromodulation to treat pain after ambulatory breast surgery: A randomized, double-masked, sham-controlled pilot study.

Brian M Ilfeld, Wendy B Abramson, Engy T Said, Jacklynn F Sztain, John J Finneran, Jonna L Griggs, Baharin Abdullah, Evan J Jensen, Adam Schaar, Anne M Wallace

Registry-linked trialAbstract read
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In one paragraph

Article in Canadian journal of pain = Revue canadienne de la douleur, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07463430 (Suzetrigine for Non-Mastectomy Breast Surgery), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07463430 phase4enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Suzetrigine for Non-Mastectomy Breast Surgery: A Non-Randomized, Prospective Study With Historic Controls

TypeinterventionalSponsorUniversity of California, San DiegoRan2026 to 2027Enrolled120ConditionsPain, Acute Postoperative, Breast DiseaseArmssuzetrigine
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brian M IlfeldDepartment of Anesthesiology, University California San Diego, San Diego, California, USA.
Wendy B AbramsonDepartment of Anesthesiology, University California San Diego, San Diego, California, USA.
Engy T SaidDepartment of Anesthesiology, University California San Diego, San Diego, California, USA.
Jacklynn F SztainDepartment of Anesthesiology, University California San Diego, San Diego, California, USA.
John J FinneranDepartment of Anesthesiology, University California San Diego, San Diego, California, USA.
Jonna L GriggsDepartment of Surgery, University California San Diego, San Diego, California, USA.
Baharin AbdullahDepartment of Anesthesiology, University California San Diego, San Diego, California, USA.
Evan J JensenAnesthesia Transitional Year Intern, Scripps Mercy Hospital, San Diego, California, USA.
Adam SchaarDepartment of Anesthesiology, University California San Diego, San Diego, California, USA.
Anne M WallaceDepartment of Surgery, University California San Diego, San Diego, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Percutaneous auricular neuromodulation involves implanting electrodes around the ear and administering an electric current. A device is currently available that is cleared to treat symptoms from opioid withdrawal, and multiple reports suggest a possible postoperative analgesic effect. This randomized, controlled pilot study aimed to (1) assess the feasibility of a postoperative auricular neuromodulation protocol and (2) provide an estimate of its treatment effects on postoperative pain and opioid consumption. Methods: Adults undergoing unilateral or bilateral ambulatory breast surgery with anticipated moderate-severe pain and a single-injection paravertebral nerve block(s) received an auricular neuromodulation device (NSS-2 Bridge, Masimo) following surgery. Participants were randomized to 5 days of electrical stimulation or sham in a double-masked fashion. Results: In the first 5 days, the median pain for those receiving active stimulation ( Conclusions: This pilot study demonstrates that percutaneous auricular neuromodulation is a feasible approach for managing pain in ambulatory surgical procedures and shows potential as an effective analgesic following discharge. Considering its ease of application, absence of systemic side effects, and lack of significant complications, conducting a definitive clinical trial seems justified because the current study was underpowered, which possibly resulted in the lack of statistical significance for the primary outcome.

Indexed as

acute post-operative painPainpostoperativepostoperative painpost-surgical painpostsurgical pain

Identifiers

PMID40657450
PMCPMC12247084

What Socratic holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.