Evidence map›Paper›PMID 40657493›Full record

ArticlePRX life

Hair Cells in the Cochlea Must Tune Resonant Modes to the Edge of Instability without Destabilizing Collective Modes.

Asheesh S Momi, Michael C Abbott, Julian Rubinfien, Benjamin B Machta, Isabella R Graf

Abstract read
In one paragraph

Article in PRX life. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Asheesh S MomiDepartment of Physics, Yale University, New Haven, Connecticut 06520, USA.ORCID 0009-0001-3109-5466
Michael C AbbottDepartment of Physics, Yale University, New Haven, Connecticut 06520, USA.ORCID 0000-0003-1091-6357
Julian RubinfienDepartment of Physics, Yale University, New Haven, Connecticut 06520, USA.ORCID 0000-0002-2501-3612
Benjamin B MachtaDepartment of Physics, Yale University, New Haven, Connecticut 06520, USA.ORCID 0000-0001-9065-614X
Isabella R GrafDepartment of Physics, Yale University, New Haven, Connecticut 06520, USA.ORCID 0000-0001-9169-9109

Funding

Physics and Systems Biology of Cellular DomainsR35GM138341 · NIGMS · YALE UNIVERSITY · PI MACHTA, BENJAMIN BROOKS · 2020 to 2024
$2.0M
NIGMS NIH HHS R35 GM138341
6 · The paper itself

Abstract

Sound produces surface waves along the cochlea's basilar membrane. To achieve the ear's astonishing frequency resolution and sensitivity to faint sounds, dissipation in the cochlea must be canceled via active processes in hair cells, effectively bringing the cochlea to the edge of instability. But how can the cochlea be globally tuned to the edge of instability with only local feedback? To address this question, we use a discretized version of a standard model of basilar membrane dynamics but with an explicit contribution from active processes in hair cells. Surprisingly, we find the basilar membrane supports two qualitatively distinct sets of modes: a continuum of

Identifiers

PMID40657493
PMCPMC12252909

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.