Evidence map›Paper›PMID 40657550›Full record

ArticleInnovation in aging2025

Gait Variability Is Associated With Gray Matter Volumes Implicated in Cognitive Function: A Cross-Sectional Analysis From the AGUEDA Trial.

Isabel Martín-Fuentes, Patricio Solis-Urra, Emilio J Ruiz-Malagón, Andrea Coca-Pulido, Angel Toval, Beatriz Fernandez-Gamez, Marcos Olvera-Rojas, Darío Bellón, Alessandro Sclafani, Jose Mora-Gonzalez and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innovation in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Isabel Martín-FuentesFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.ORCID https://orcid.org/0000-0003-4268-1935
Patricio Solis-UrraAdventHealth Research Institute, Neuroscience, Orlando, Florida, USA.ORCID https://orcid.org/0000-0002-2493-9528
Emilio J Ruiz-MalagónFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Andrea Coca-PulidoFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Angel TovalFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Beatriz Fernandez-GamezFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Marcos Olvera-RojasFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Darío BellónFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Alessandro SclafaniFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Jose Mora-GonzalezFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Lucía Sánchez-ArandaFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Javier Sanchez-MartinezFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
José Pablo Martínez-BarberoNuclear Medicine Services, Servicio de Radiodiagnóstico, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Manuel Gómez-RíoNuclear Medicine Services, Servicio de Radiodiagnóstico, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Teresa Liu-AmbroseFaculty of Medicine, Department of Physical Therapy, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-8297-5308
Kirk I EricksonAdventHealth Research Institute, Neuroscience, Orlando, Florida, USA.
Francisco B OrtegaFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Irene Esteban-CornejoFaculty of Sport Sciences, Department of Physical Education and Sports, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.ORCID https://orcid.org/0000-0002-0027-1770

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Aging is associated with both gait impairments and cognitive decline; however, the relationship between specific gait variability parameters, gray matter volume (GMV), and cognitive function remains poorly understood. This study aims to examine the associations between gait variability parameters (derived from stride length, step length, step time, and gait velocity) and GMV and its associations with cognitive function in cognitively normal older adults. Research Design and Methods: Eighty-seven older adults (48 female) aged 65-80 from the AGUEDA trial participated in this cross-sectional analysis. The Optogait system was used to record gait parameters. T1-weighted brain images were acquired magnetic resonance imaging scanner, and GMV was calculated by whole-brain voxel-based morphometric analysis using SPM12. Cognitive function was calculated from different cognitive tests. Results: Greater stride length variability was associated with lower GMV ( Discussion and Implications: These results suggest that gait variability could be an indicator of neurocognitive decline in older adults. Understanding these associations is essential for early dementia detection and sheds light on the complex interplay between physical function, brain health, and cognitive function during aging.

Indexed as

Brain structureBrain volumesGait inconsistencyMagnetic resonance imaging

Identifiers

PMID40657550
PMCPMC12246678

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.