ArticleThe journal of poultry science2025
Effects of Aging on the Microbiota and Inflammatory Status of the Intestinal and Oviductal Mucosa in Laying Hens.
Article in The journal of poultry science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Integrated network pharmacology and in vivo validation reveal the action of Scutellaria baicalensis extract against oviductal inflammation in laying hens.Poultry science · 2026Article
- L. AGILIS ALLEVIATES SALPINGITIS IN HENS Lactobacillus agilis alleviates salpingitis through the TLR4/MyD88/NF-κB pathway and gut microbiota interactions in aged laying hens.Poultry science · 2026Article
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Authors and funding
5 authors.
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Abstract
Aging and inflammation of the intestinal and oviductal mucosa reduce egg production in laying hens. In mammals, microbiota changes in the intestine and reproductive mucosa are linked to aging and mucosal inflammation, but this relationship remains unclear in hens. The present study aimed to investigate the impact of aging on microbiota and inflammation in the intestinal and oviductal mucosa of hens. Sixteen White Leghorn hens aged ~280 days (young) and ~730 days (aged) were used. Bacterial DNA was extracted from feces and vaginal swabs for 16S rRNA amplicon sequencing. Intestinal (ileum and cecum) and oviductal (uterus and vagina) tissues were processed for histological analysis. Real-time PCR was performed to profile pro- and anti-inflammatory cytokines, tight junction-related molecules, and calbindin in the uterus. Whereas microbial diversity and composition in the vagina did not change with age; alpha-diversity of intestinal bacteria was lower in the aged group, as suggested by 46 genera showing a decrease and five an increase. The morphology of the ileum mucosa deteriorated, with transforming growth factor (
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