Co-stimulation with equibiaxial strain and pre-osteoblast co-culture differentiates monocytes in a bone model.

Maria R Ward Rashidi, Catherine S Snyder, Kathleen M Burkhard, Raneem Ahmad, Isha Bhorkar, Geeta Mehta

Abstract read

In one paragraph

Article in MRS communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maria R Ward Rashidi *Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109 USA.

Catherine S Snyder *Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109 USA.

Kathleen M Burkhard *Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 USA.

Raneem AhmadDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109 USA.

Isha BhorkarDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 USA.ORCID 0000-0002-7258-8275

Geeta MehtaDepartment of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109 USA.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gary D Luker · 1988 to 2026

$178.2M

NCI NIH HHS P30 CA046592

6 · The paper itself

Abstract

Bone remodeling and immune function are dynamically regulated through cell-cell and cell-matrix interactions by stem and mature cell populations. We investigated the hypothesis that monocytes and pre-osteoblasts respond to cyclic tensile stress and paracrine interactions by differentiating into macrophage-like and osteoblast-like cells. 20% cyclic equibiaxial strain was applied to monocytic U937 and pre-osteoblastic ST2 cells for 72 h. Increased levels of CD11B, CD14, IL-6, and IL-8 in U937 indicated monocytic differentiation. Increased ALP expression and calcium deposition in ST2 indicated differentiation towards osteoblastic lineage. Overall, application of cyclic strain and pre-osteoblastic co-culture induced differentiation in this cyclically strained bone model. Graphical abstract:

Indexed as

BiomaterialBiomimeticBoneFunctionalModelingMorphologyTissueTunable

Identifiers

PMID40657606

DOI10.1557/s43579-025-00711-2

PMCPMC12241300

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.