ArticleMagnetic resonance (Gottingen, Germany)2025
ih-RIDME: a pulse EPR experiment to probe the heterogeneous nuclear environment.
Article in Magnetic resonance (Gottingen, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Quantifying the liquid-liquid transition in cold water/glycerol mixtures by intermolecular hyperfine relaxation-induced dipolar modulation enhancement (ih-RIDME).Physical chemistry chemical physics : PCCP · 2025Article
- Tracking life and death of carbon nitride supports in platinum-catalyzed vinyl chloride synthesis.Nature communications · 2025Article
- ih-RIDME: a pulse EPR experiment to probe the heterogeneous nuclear environment.Magnetic resonance (Gottingen, Germany) · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intermolecular hyperfine relaxation-induced dipolar modulation enhancement experiment (ih-RIDME) is a pulse electron paramagnetic resonance (EPR) experiment that can be used to probe the properties of a nuclear spin bath in the vicinity of an unpaired electron. The underlying mechanism is the hyperfine spectral diffusion of the electron spin during the mixing block. A quantitative description of the diffusion kinetics being applied to establish the ih-RIDME data model allows one to extend this method to systems with heterogeneous nuclear arrangements assuming a distribution of the local nuclear densities. The heterogeneity can stem from the solvent or the intrinsic nuclei of a structurally flexible (macro)molecule. Therefore, the fitted distribution function can further serve as a method for heterogeneity characterization, quantification and structure-based analysis. Here, we present a detailed introduction to the principles of ih-RIDME application to heterogeneous systems. We discuss the spectral resolution, determination of the spectral diffusion parameters and influence of noise in the experimental data. We further demonstrate the application of the ih-RIDME method to a model spin-labelled macromolecule with unstructured domains. The fitted distribution of local proton densities was reproduced with the help of a conformational ensemble generated using the Monte Carlo approach. Finally, we discuss several pulse sequences exploiting the HYperfine Spectral Diffusion Echo MOdulatioN (HYSDEMON) effect with an improved signal-to-noise ratio.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.