ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- DietaryAnimals : an open access journal from MDPI · 2026Article
- Landscape Genomics Reveals Divergent Adaptation Modes and Predicts Climate Vulnerability in Xinjiang Indigenous Sheep.Animals : an open access journal from MDPI · 2026Article
- Integrating landscape genomics and machine learning to analyze the genetic structure and specific molecular markers of Chinese dairy goats (Capra hircus).Journal of animal science and biotechnology · 2026Article
- Screening of Candidate SNPs Potentially Associated with Multi-Parity Litter Size and Litter Weight in Hu Sheep.Animals : an open access journal from MDPI · 2026Article
- Circulating microRNAs reveal egg-brain crosstalk and a brain-predominant microRNA linked to the onset of the next reproductive cycle in iteroparous salmonids.BMC biology · 2026Article
- Multi-Omics Epigenetic Landscape Unveils Regulatory Mechanisms Underlying Heterosis in Sheep Muscle Development.Animals : an open access journal from MDPI · 2026Article
- Functional Characterization ofAnimals : an open access journal from MDPI · 2026Article
- Article
- Genomic insights into the recent evolution and biodiversity of Italian sheep breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Hu sheep are renowned for their adaptation to high-temperature, humid environments and their high fecundity. Despite serving as the founder species for sheep breeding in China, the genetic mechanisms underlying these desirable traits and the breed's origin have remained unresolved. To address the longstanding challenges in understanding their adaptations and origins, comprehensive analyses utilizing genetic data is conducted from over 300 Hu sheep and ≈200 other Chinese native sheep. The study unveils the migration history of sheep and the formation of the Hu sheep in eastern China. By employing multiple screening methods, this study identifies that the BMPR1B, UNC5C, and GRID2 synergistically contribute to the high fecundity trait in Hu sheep. The coexistence of beneficial genotypes in these genes increase the likelihood of multiple births. Notably, the results suggest a potential coevolution between environmental adaptation and reproductive traits in this breed. Overall, the study provides novel insights into the genetic origin and adaptation of Hu sheep, offering new perspectives for molecular breeding in sheep and other livestock species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.