Evidence map›Paper›PMID 40658097›Full record

ArticleeLife2025

PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation.

Li He, Jiayu Wen, Qi Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Li HeDepartment of Molecular Bioscience, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-4743-5410
Jiayu WenDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, The Australian National University and Australian Research Council Centre of Excellence for the Mathematical Analysis of Cellular Systems, Canberra, Australia.ORCID https://orcid.org/0000-0003-1249-6456
Qi DaiDepartment of Molecular Bioscience, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-2082-0693

Funding

Australian Research Council Centre of Excellence for the Mathematical Analysis of Cellular Systems CE230100001Cancerfonden 20 1046 PjF 01 HCancerfonden CAN 2017/529Vetenskapsrådet 2020-03543
6 · The paper itself

Abstract

BMP signaling acts as an instructive cue in various developmental processes such as tissue patterning, stem cell proliferation, and differentiation. However, it is not fully understood how this signaling pathway generates different cell-specific outputs. Here, we have identified PRDM16 as a key co-factor for BMP signaling in the mouse brain. PRDM16 contributes to a repressive role of BMP signaling on neural stem cell (NSC) proliferation. We demonstrate that PRDM16 regulates the genomic distribution of BMP pathway transcription factors, the SMAD4/pSMAD complex, preventing the activation of cell proliferation genes. When

Indexed as

Bone Morphogenetic ProteinsCell ProliferationDNA-Binding ProteinsNeural Stem CellsSignal TransductionTranscription FactorsAnimalsMiceSmad4 ProteinBone Morphogenetic ProteinsDNA-Binding ProteinsPrdm16 protein, mouseSmad4 ProteinTranscription FactorsBMP signalingchoroid plexusdevelopmental biologymousePRDM16regenerative medicinestem cell proliferationstem cellsWnt signaling

Identifiers

PMID40658097
PMCPMC12259022

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.