Evidence map›Paper›PMID 40658605›Full record

ArticleeLife2025

Hong Huang, Ying Yang, Qiuju Zhang, Yongfeng Yang, Zhenqi Xiong, Shengqiang Mao, Tingting Song, Yilong Wang, Zhiqiang Liu, Hong Bu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. eLife · 2025
    Article
  4. Article
  5. Developing a quantum computing model for sequence annotation of interferon protein.Computational and structural biotechnology journal · 2025
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hong Huang *Institute of Clinical Pathology, Key Laboratory of Transplantation Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-2706-1570
Ying Yang *Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-1871-3119
Qiuju ZhangCollege of Computer Science, Sichuan University, Chengdu, China.ORCID https://orcid.org/0009-0000-9454-6650
Yongfeng YangInstitute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-8109-9801
Zhenqi XiongCollege of Computer Science, Sichuan University, Chengdu, China.ORCID https://orcid.org/0009-0005-6128-9965
Shengqiang MaoInstitute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0001-5431-2227
Tingting SongInstitute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0001-8965-3793
Yilong WangInstitute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0009-0007-8130-8857
Zhiqiang LiuInstitute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-7684-968X
Hong BuInstitute of Clinical Pathology, Key Laboratory of Transplantation Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0001-7472-6443
Li ZhangInstitute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0003-1125-1991
Le ZhangCollege of Computer Science, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-3708-1727

Funding

National Natural Science Foundation of China 62372316National Natural Science Foundation of China 92159302National Science and Technology Major Project 2021YFF1201200National Science and Technology Major Project 2024ZD0532900Sichuan Science and Technology Program Key Project 2024YFHZ0091Sichuan Science and Technology Project 2022ZDZX0018West China Hospital, Sichuan University ZYGD2200
6 · The paper itself

Abstract

Lung cancer is preceded by premalignant lesions, and what factors drive this transformation and the potential regulatory mode in the context of tumor initiation remain to be elucidated. In the course of precancerous lesions in mice, we found a phasic shift in metabolic patterns. Macrophages are a heterogeneous cell population with high plasticity in the tumor microenvironment. Single-cell interaction and metabolic analyses highlighted a cellular state,

Indexed as

Fatty AcidsHyperplasiaLung NeoplasmsMacrophages, AlveolarNeovascularization, PathologicPrecancerous ConditionsS100 Calcium-Binding Protein A4AnimalsDisease ProgressionHumansMiceFatty AcidsS100A4 protein, humanS100a4 protein, mouseS100 Calcium-Binding Protein A4alveolar macrophageangiogenesisatypical adenomatous hyperplasiacancer biologyfatty acid metabolismhumanlung cancermouseprecancerous lesion

Identifiers

PMID40658605
PMCPMC12259021

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.