Observational studyPloS one2025
Predictive factors for failure of high flow nasal cannula among children with lower respiratory tract infection: A single center retrospective observational study.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High-flow nasal cannula versus continuous positive airway pressure for noninvasive respiratory support in children with bronchiolitis: a meta-analysis of randomized controlled trials.Frontiers in pediatrics · 2026Pooled it
- Clinical Predictors of High-Flow Nasal Cannula Failure in Children with Acute Respiratory Illness: A Single-Center Experience.Indian journal of pediatrics · 2026Article
- Tools for Monitoring Respiratory Distress in Heated Humidified High-flow Nasal Cannula in Children: How do We Score the Scores?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveLower respiratory tract infection (LRTI) is a leading cause of childhood hospitalization worldwide, with high-flow nasal cannula (HFNC) therapy commonly employed as a non-invasive respiratory support method. Determining early predictors of HFNC failure is crucial for timely intervention and reducing associated morbidity and mortality.
methodsWe retrospectively reviewed the medical records of hospitalized children aged 1 month to 18 years with LRTI who received HFNC from January 2016 to December 2021. We aimed to evaluate predictive factors for HFNC failure and identify optimal cutoffs from the AUROC (AUROC).
resultsOne hundred and sixteen children with LRTI applied to HFNC were included in this study. Most of them (90.5%) were diagnosed with pneumonia as a principal diagnosis, and 68.9% had co-morbidities. Of those, 18 patients (15.5%) needed escalation to intubation and were defined as HFNC failure. The early predictive parameters associated with HFNC failure were pulse rate at 2 hours and SpO2/FiO2 ratio at 4 hours. AUROC analysis for the predictive parameter of HFNC failure showed cut-off values of S/F ratio at 4 hours after HFNC therapy was lower than 238 (AUC 0.89, 95%CI: 0.78-0.99).
conclusionSpO2/FiO2 at 4 hours after initiating HFNC appeared to be a predicting value for early detected failure for HFNC therapy in children with LRTI. Close monitoring and swift management adjustments are recommended for children exhibiting these risk factors to enhance outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.