ArticlePloS one2025
Metabolomics analysis and mRNA/miRNA profiling reveal potential cardiac regulatory mechanisms in Yili racehorses under different training regimens.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Article
- Cardiac-Metabolic Coupling Revealed by Lipid and Energy Metabolomics Determines 80 km Endurance Performance in Yili Horses.Biology · 2025Article
- Multi-Omics Deciphers Divergent Mechanisms in Differentially Cardiac-Remodeled Yili Horses Under Conditions of Equivalent Power Output.Animals : an open access journal from MDPI · 2025Article
- Comparative analysis of miRNA expression in Yili horses pre- and post-5000-m race.Frontiers in genetics · 2025Article
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Yili horses, a versatile breed from Xinjiang, China, are renowned for their racing abilities. However, studies on the links between cardiac morphology, function, and metabolic profiles with performance are limited. This study combined echocardiographic, transcriptomic, and metabolomic analyses to explore these relationships in high-level, average, and untrained Yili horses. Echocardiographic assessments revealed increased left ventricular mass in trained horses, with significant differences in intraventricular septal thickness and left ventricular end-diastolic diameter. RNA sequencing identified 534 differentially expressed genes, 366 differentially expressed miRNAs, highlighting pathways in glycine, serine, and threonine metabolism, oxygen transport (e.g., ALAS2), and ATP generation. Metabolomic analysis revealed variations in acylcarnitine and triglycerides, suggesting training-induced cardiac remodeling regulated by miRNAs. This integrated approach provides new insights into the molecular and metabolic factors influencing performance, offering a foundation for optimized training strategies for Yili horses.
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Registered trials
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