ArticleJournal of visualized experiments : JoVE2025
High-density Multielectrode Array Recordings of Retinal Waves Using An Electrophysiology Platform.
Article in Journal of visualized experiments : JoVE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Mouse model of Angelman syndrome exhibits reduced retinal activity during development.Frontiers in neuroscience · 2026Article
- Retinal waves reveal axial biases in modular patterns of cortical activity that predict future orientation preferences.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Spontaneous retinal waves are a hallmark of retinal network activity during development, playing a crucial role in the formation of the visual system by influencing the refinement of axons, permeability of vasculature, and overall maturation of neural circuits. These waves are commonly studied in ex vivo retinal preparations using multielectrode arrays (MEAs), which enable electrophysiological recordings of large populations of retinal ganglion cell (RGC) activity. MEA-based electrophysiology has become a powerful tool due to its ease of use to rapidly collect high-throughput data, thus making it ideally suited to study retinal activity in a variety of experimental conditions. In this protocol, we outline the critical steps for preparing retinal tissue for the acquisition of electrophysiological data using a High-Density MEA (HD-MEA) on an electrophysiology platform. The process begins with the careful isolation of intact retinas from neonatal animals under physiological conditions. Once prepared, the retina is carefully mounted onto an HD-MEA chip, which consists of a grid of 26,400 electrodes capable of performing simultaneous extracellular recordings from at least 1,000 RGCs. Recordings can last up to several hours. Ultimately, this methodological approach offers valuable applications in investigating retinal development, disease, and potentially cross-species comparative studies, contributing to broader advancements in neuroscience and vision research.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.