Evidence map›Paper›PMID 40659490›Full record

ArticleLife science alliance2025

The rewiring of cAMP/cGMP and LDH signalling drives cardiac hypertrophy in

Ana Gabriela de Oliveira do Rêgo, Sonia Maccari, Giuseppe Marano, Tonino Stati, Michele Saliola, Mauro Giorgi, Silvia Cardarelli, Matilde Merolle, Francesco Tomassoni-Ardori, Lino Tessarollo and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ana Gabriela de Oliveira do RêgoDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-0093-9379
Sonia MaccariCenter for Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0002-7085-7996
Giuseppe MaranoCenter for Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0002-8748-0312
Tonino StatiCenter for Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Michele SaliolaDepartment of Biology and Biotechnology "C. Darwin", Sapienza University, Rome, Italy.
Mauro GiorgiDepartment of Biology and Biotechnology "C. Darwin", Sapienza University, Rome, Italy.
Silvia CardarelliDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy.
Matilde MerolleInstitute of Biochemistry and Cell Biology, IBBC-CNR, Rome, Italy.ORCID 0000-0002-0246-6985
Francesco Tomassoni-ArdoriNeural Development Section, Mouse Cancer Genetics Program, Center for Cancer Research, NCI, NIH, Frederick, MD, USA.
Lino TessarolloNeural Development Section, Mouse Cancer Genetics Program, Center for Cancer Research, NCI, NIH, Frederick, MD, USA.
Federica CampoloDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy.
Andrea M IsidoriDepartment of Experimental Medicine, Sapienza University, Rome, Italy.ORCID 0000-0002-9037-5417
Luciana De AngelisDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy.
Fabio NaroDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-0572-5900
Lucia MonacoDepartment of Physiology and Pharmacology, Sapienza University, Rome, Italy.
Manuela PellegriniDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy manuela.pellegrini@cnr.it.ORCID 0000-0001-6387-5187

Funding

Intramural Research Program of National Cancer Institute, NIH
6 · The paper itself

Abstract

Phosphodiesterase type 5a (Pde5a), an enzyme that hydrolyzes cGMP nucleotide, regulates several aspects of heart physiology and its inhibition improves left ventricular heart function under pathological conditions. We investigated Pde5a role in the development and progression of moderate and severe cardiac hypertrophy, induced by transverse aortic constriction (TAC), in Pde5a WT (

Indexed as

CardiomegalyCyclic AMPCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5L-Lactate DehydrogenaseAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutPhosphodiesterase 5 InhibitorsSignal TransductionSildenafil CitrateCyclic AMPCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5L-Lactate DehydrogenasePde5a protein, mousePhosphodiesterase 5 InhibitorsSildenafil Citrate

Identifiers

PMID40659490
PMCPMC12261138

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.