ArticleNature communications2025
A neurofunctional signature of affective arousal generalizes across valence domains and distinguishes subjective experience from autonomic reactivity.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural systems underlying autobiographical memory dysregulations in depression: A neuroimaging meta-analysis.Psychological medicine · 2025Pooled it
- Vasopressin and angiotensin II pathways differentially modulate human fear response dynamics to looming threats.PLoS biology · 2026Trial
- Disgust Propensity, Not Disgust Sensitivity, Shapes the Reactivity of a Subjective Disgust Circuit in Humans.Human brain mapping · 2026Article
- Latent neural architecture organising shared aesthetic evaluations of visual artworks.Nature communications · 2026Article
- Intermittent Theta-Burst Stimulation (iTBS) Modulates Abnormal Brain Activity During Emotional Arousal in Adolescent Depression: A Pilot Study.Brain topography · 2026Article
- Deep cross-modal affective memory networks with adaptive multi-source heterogeneous transfer learning in speech emotion recognition.Scientific reports · 2026Article
- Common and distinct neurofunctional signatures of dynamic naturalistic emotion regulation strategies.Nature communications · 2026Article
- Research on the emotional generation mechanism and optimization pathways of traditional village landscapes in northeastern Hubei based on EEG measurements.Frontiers in psychology · 2026Article
- A corticospinal signature for interindividual pain sensitivity.Nature communications · 2025Article
- Dynamic brain connectivity predicts emotional arousal during naturalistic movie-watching.PLoS computational biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Arousal is fundamental for affective experience and, together with valence, defines the core affective space. Precise brain models of affective arousal are lacking, leading to continuing debates of whether the neural systems generalize across valence domains and are separable from those underlying autonomic arousal or wakefulness. Here, we combine naturalistic fMRI with predictive modeling to develop a brain affective arousal signature (BAAS, discovery-validation design, n = 60, 36). We demonstrate its (1) sensitivity and generalizability across mental processes, valence, and stimulation modality and (2) neural distinction from autonomic arousal and wakefulness (24 studies, n = 868). Affective arousal is encoded in distributed cortical-subcortical (e.g., prefrontal, periaqueductal gray) systems with local similarities in thalamo-amygdala-insula systems between affective and autonomous arousal. We demonstrate application of the BAAS to improve specificity of established valence-specific neuromarkers. Our study provides a biologically plausible model for affective arousal that aligns with the affective space and has a high application potential.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.