In vitro and in silico evaluation of phytocompounds from Leucaena leucocephala and Entada phaseoloides targeting DNA gyrase, topoisomerase II, AKT1.

Laldinliana Khiangte, Hmingremhlua Sailo, Laldinfeli Ralte, F Lalnunmawia, N Senthilkumar, Yengkhom Tunginba Singh

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

6 authors.

Laldinliana KhiangteDepartment of Botany, Mizoram University, Aizawl, Mizoram, 796004, India.

Hmingremhlua SailoDepartment of Botany, Mizoram University, Aizawl, Mizoram, 796004, India.

Laldinfeli RalteDepartment of Botany, Mizoram University, Aizawl, Mizoram, 796004, India.

F LalnunmawiaDepartment of Botany, Mizoram University, Aizawl, Mizoram, 796004, India.

N SenthilkumarDepartment of Biotechnology, Mizoram University, Aizawl, Mizoram, 796004, India.

Yengkhom Tunginba SinghDepartment of Life Sciences (Botany), Manipur University, Imphal, Manipur, 795003, India. tunginba@manipuruniv.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medicinal plants are rich in bioactive phytochemicals with the potential to treat various ailments, including cancer and infectious diseases. Leucaena leucocephala and Entada phaseoloides have long been used in traditional medicine for such conditions. This study investigated the phytochemical composition, antioxidant, antibacterial, and anticancer potential of methanolic pod extracts of both species through integrated in vitro and in silico approaches. L. leucocephala exhibited higher total phenolic content (49.02 ± 0.43 GAE/g) and total flavonoid content (77.95 ± 0.32 QE/g) than E. phaseoloides (TPC: 42.30 ± 0.13 GAE/g; TFC: 72.90 ± 0.42 QE/g). Phytochemicals were characterized via FTIR and LC-MS, identifying 54 compounds. Antioxidant activity assessed by DPPH and ABTS assays showed stronger radical scavenging in L. leucocephala (IC

Indexed as

DNA GyraseFabaceaePhytochemicalsPlant ExtractsProto-Oncogene Proteins c-aktTopoisomerase II InhibitorsAnti-Bacterial AgentsAntioxidantsDNA Topoisomerases, Type IIHeLa CellsHumansMolecular Docking SimulationAKT1 protein, humanAnti-Bacterial AgentsAntioxidantsDNA GyraseDNA Topoisomerases, Type IIPhytochemicalsPlant ExtractsProto-Oncogene Proteins c-aktTopoisomerase II InhibitorsCytotoxicityEntada phaseoloidesFTIRLC–MSLeucaena leucocephalaMolecular dockingNetwork pharmacology

Identifiers

PMID40659692

DOI10.1038/s41598-025-07792-y

PMCPMC12259877

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.