ArticleScientific reports2025
A novel electrochemical immunosensor based on biomaterials for detecting carcinoembryonic antigen biomarker in serum samples.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A signal-on fluorescent probe integrating Au@Ag NPs-based fluorescence resonance energy transfer quenching and enzyme-free catalytic hairpin assembly for c arcinoembryonic antigen detection.Mikrochimica acta · 2026Article
- Why Sensors Fail in Biological Samples: Fouling, Blocking, Matrix Effects and Prevention Solutions.International journal of molecular sciences · 2026Review
- Electrochemical liquid biopsy across cancer care pathway.The journal of liquid biopsy · 2026Review
- Built-in thiol mesoporous carbon immunosensor to detect carcinoembryonic antigen in human serum.Mikrochimica acta · 2026Article
- Electrochemical Biosensors for Cancer Diagnosis and Prognosis Using Protein Biomarkers: Current Trends, Advances, and Clinical Translation Potential.Sensors (Basel, Switzerland) · 2026Review
- Rapid Detection of SARS-CoV‑2 Spike Protein Using a Fully 3D-Printed Electrochemical Biosensor.ACS omega · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
A new label-free electrochemical immunosensor was developed to detect carcinoembryonic antigen (CEA), a key diagnostic biomarker for various cancers. The surface of a glassy carbon electrode (GCE) was modified using a layer-by-layer assembly method incorporating sodium alginate (SA), gold nanoparticles (AuNPs), and gamma-manganese dioxide/chitosan (γ.MnO₂-CS). This modification enhanced the functional surface area and electrode conductivity, thereby improving the electrochemical response and sensitivity for CEA detection. Methods including cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to evaluate the immunosensor`s performance.The sensor quantified CEA concentrations in serum samples by monitoring current variations at the oxidation peak, resulting from the formation of CEA antibody-CEA antigen complexes on the electrode surface. The sensor exhibited a linear response to CEA concentrations ranging from 10 fg/mL to 0.1 µg/mL, with a limit of detection (LOD) of 9.57 fg/mL and a limit of quantification (LOQ) of 31.6 fg/mL. The morphology and structural properties of the synthesized γ.MnO₂-CS nanocomposite and the modified electrode surface were characterized utilizing field-emission scanning electron microscopy (FE-SEM), Brunauer-Emmett-Teller (BET) and Barrett-Joyner-Halenda (BJH), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), dynamic light scattering (DLS), zeta potential analysis, and Fourier transform infrared (FTIR) spectroscopy. The results highlight the potential clinical applicability of this electrochemical immunosensor for detecting CEA levels in human serum samples.
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