Evidence map›Paper›PMID 40659883›Full record

ArticlePediatric surgery international2025

Perioperative outcomes of neonatal versus delayed surgery for Hirschsprung disease: a nationwide retrospective cohort study in Japan.

Mai Kutsukake, Shotaro Aso, Takaaki Konishi, Michimasa Fujiogi, Naohiro Takamoto, Yoshitsugu Yanagida, Kaori Morita, Kiyohide Fushimi, Hiroki Matsui, Hideo Yasunaga and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Mai KutsukakeDepartment of Pediatric Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan.
Shotaro AsoDepartment of Health Service Research, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan.
Takaaki KonishiDepartment of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan.
Michimasa FujiogiDepartment of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan.
Naohiro TakamotoDepartment of Pediatric Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan.
Yoshitsugu YanagidaDepartment of Pediatric Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan.
Kaori MoritaDepartment of Pediatric Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan.
Kiyohide FushimiDepartment of Health Policy and Informatics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, Japan.
Hiroki MatsuiDepartment of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan.
Hideo YasunagaDepartment of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan.
Jun FujishiroDepartment of Pediatric Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, Japan. fujishiroj-psu@h.u-tokyo.ac.jp.

Funding

the Ministry of Health, Labour and Welfare, Japan 23AA2003 and 24AA2006
6 · The paper itself

Abstract

purposeTo assess the safety and short-term outcomes of neonatal surgery for Hirschsprung disease.

methodsThis retrospective cohort study extracted data from a nationwide Japanese inpatient database from July 2010 to March 2021. Patients diagnosed with Hirschsprung disease within 30 days of life who underwent definitive surgery within 120 days of life were identified. Patients who underwent enterostomy before definitive surgery and those who were diagnosed with the extended type of Hirschsprung disease were excluded. We stratified patients who underwent definitive surgery within 30 days of life into the neonatal group (n = 65), and the others into the non-neonatal group (n = 300). Propensity-score overlap weighting analyses were employed to compare the outcomes between the two groups.

resultsOverlap weighting analysis revealed no significant difference in in-hospital morbidity (risk difference [95% confidence interval], -4.6 [-16.8-7.5]). Although the post-operative length of stay was longer (difference, 6.5 [-0.1 to -13.0] days), the total length of stay during infancy (difference, 14.6 [6.3 to 22.8] days) was shorter in the neonatal group than in the non-neonatal group.

conclusionsThis nationwide cohort study found that although in-hospital morbidity was similar between definitive surgery for Hirschsprung disease performed in the neonatal and non-neonatal periods, neonatal surgery was associated with a shorter total length of hospitalization during infancy compared with delayed surgery. In terms of the short-term outcomes, neonatal surgery for Hirschsprung disease is safe, and delayed surgery may not be beneficial.

Indexed as

Hirschsprung DiseaseTime-to-TreatmentFemaleHumansInfantInfant, NewbornJapanLength of StayMalePostoperative ComplicationsPropensity ScoreRetrospective StudiesTreatment OutcomeCosts and cost analysisLength of stayMorbidity

Identifiers

PMID40659883
PMCPMC12259758

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