ArticleNature aging2025
Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice.
Abstract read
In one paragraph
Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- SenFlag gene signature identifies senescent cells in mouse and human tissues through a conserved core transcriptional program.The EMBO journal · 2026Article
- Cellular Heterogeneity During Arterial Aging.Aging cell · 2026Review
- Research Progress on the Molecular Mechanism of LRP1 and TGFβ-PDGFRβ Signaling Network in Atherosclerosis and Vascular Remodeling.International journal of molecular sciences · 2026Review
- Cellular senescence as a therapeutic target for aging intervention.Biomedical journal · 2026Review
- Single-cell RNA sequencing reveals HMGA2 involvement in neoplastic aggressiveness and endothelial cell senescence in chondrosarcoma.Cell biology and toxicology · 2026Article
- The cGAS-STING pathway in senescence and aging-related diseases: mechanisms and therapeutic opportunities.Cell communication and signaling : CCS · 2026Review
- Considerations in the Use of Mouse Models of Vascular and Valvular Calcification.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- A Comprehensive Review of Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease.Biomolecules · 2026Review
- Identification of core genes and transcription factors related to metabolic reprogramming in atherosclerosis: a multi-omics analysis and experimental validation approach.Frontiers in molecular biosciences · 2026Article
- Sirtuin 1 is a key molecular link between cellular senescence and heart failure.Frontiers in molecular medicine · 2026Review
- Vascular smooth muscle cell metabolic reprogramming and phenotypic remodeling in atherosclerosis.Cell death discovery · 2025Review
- The Emerging Role of Senolysis in Atherosclerosis.Medicina (Kaunas, Lithuania) · 2025Review
- Immune-mediated interactions between sarcopenia and atherosclerosis in aging.Immunity & ageing : I & A · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Krystyna Mazan-Mamczarz *Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.ORCID http://orcid.org/0009-0005-1545-0500
Dimitrios Tsitsipatis *Laboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA.
Bennett G ChildsDepartment of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-6078-0588
Angelica E CarrLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-9094-646X
Carla Rocha Dos SantosLaboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA.
Carlos AnerillasLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-4424-7913
Brigette RomeroDepartment of Medical and Molecular Sciences, University of Delaware, Newark, DE, USA.
Jordan M GreggLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-2024-8586
Charnae' Henry-SmithLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.
Ada N OkerekeLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.
Marc MichelLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.
Rachel MunkLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.
Jennifer L MartindaleLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3234-6861
Yulan PiaoLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.
Jinshui FanLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.ORCID http://orcid.org/0009-0001-9300-1920
Maria O HernandezCenter for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA.
Noemi KedeiCenter for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA.
Michael L ViacheslavovSeqmatic LLC, Fremont, CA, USA.
Madeline M F WongCenter for Cancer Research, National Cancer Institute IRP, NIH, Bethesda, MD, USA.
Olga V FedorovaLaboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA.
Mona BatishDepartment of Medical and Molecular Sciences, University of Delaware, Newark, DE, USA.
Supriyo DeLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-2075-7655
Darren J BakerDepartment of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9006-1939
Myriam GorospeLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA. gorospem@grc.nia.nih.gov.ORCID http://orcid.org/0000-0001-5439-3434
Allison B HermanLaboratory of Cardiovascular Science, NIA IRP, NIH, Baltimore, MD, USA. ali.herman@nih.gov.
Funding
Analysis of vascular cell senescence to identify interventions in atherosclerosisZIAAG000491 · NIA · NATIONAL INSTITUTE ON AGING · PI HERMAN, ALLISON · 2021 to 2025
$1.9MIntramural NIH HHS ZIA AG000491
Abstract
Growing evidence suggests that the induction of cellular senescence in vascular cells is causally linked to the etiology of cardiovascular diseases. To investigate systematically the heterogeneity of senescent vascular cells in atherosclerosis, we used a high-fat diet and PCSK9 overexpression to induce atherosclerosis in a senescence reporter mouse model (p16-tdTomato
Indexed as
AtherosclerosisCellular SenescenceTranscriptomeVascular RemodelingAnimalsAortaDiet, High-FatDisease Models, AnimalFibroblastsGene Expression ProfilingHumansMaleMiceMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth Muscle
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.