ArticleBMC cardiovascular disorders2025
Effects of cardioneuroablation for vasovagal syncope: ganglionated plexus localization by tentative anatomical ablation and high-frequency electrical stimulation.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Biatrial cardioneuroablation guided by robotic magnetic navigation and artificial intelligence-based mapping in vagal bradyarrhythmias: A controlled observational study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Observational
- Cardioneuroablation for Reflex Syncope and Functional Bradyarrhythmias: A State-of-the-Art Review.Journal of clinical medicine · 2026Review
- Cardiac autonomic ganglion ablation for refractory coronary artery spasm after PCI: a case report.Frontiers in cardiovascular medicine · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundCardioneuroablation is increasingly being adopted as a treatment for vasovagal syncope (VVS). Identification of the cardiac ganglionated plexus (GP) is a critical factor influencing the outcome of the procedure. This study sought to compare the efficacy of tentative anatomical ablation (TAA) and high-frequency electrical stimulation (HFS) in locating the GP.
methodsA total of 58 patients diagnosed with VVS were consecutively enrolled, including 46 patients with the cardioinhibitory type and 12 patients with the mixed type who exhibited a significant decrease in heart rate (HR). The first 19 enrolled patients simultaneously underwent HFS- and TAA-guided GP localization. All patients underwent anatomical GP ablation.
resultsThe number of GP sites with a positive response to TAA was significantly greater than those from HFS (15 ± 4 per person vs. 12 ± 4 per person; p < 0.001). Following anatomical ablation, the patients exhibited an increase in HR (69 ± 13 bpm vs. 91 ± 13 bpm, p < 0.001), a reduction in sinus node recovery time (1155 ± 169 ms vs. 934 ± 162 ms, p < 0.001), an enhancement of atrioventricular conduction (Wenckebach point: 418 ± 87 ms vs. 338 ± 41 ms; effective refractory period of atrioventricular node: 334 ± 84 ms vs. 254 ± 54 ms, all p < 0.001), and a reduction in heart rate variability (HRV) (HRV
conclusionsIn GP localization, TAA-guided responses demonstrated greater precision and wider distribution compared to HFS-guided approaches. Anatomical GP ablation can significantly decrease autonomic tone and prevent syncope in patients with VVS. CLINICAL TRIAL NUMBER: Not applicable.
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