ArticleRespiratory research2025
Impact of natal and childhood metabolic markers on childhood asthma burden - a nationwide cohort study.
Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association between low-density lipoprotein cholesterol and the risk of bronchial asthma: a case-control study.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundPediatric obesity, a risk factor for asthma, is increasing in prevalence. Obesity-mediated metabolic abnormalities are one of the mechanisms that link asthma and obesity. While maternal obesity contributes to obesity and respiratory morbidity in the child, the contribution of paternal obesity and parental metabolic abnormalities to the child's asthma is not known.
methodsTo quantify the impact of parental and child's body weight and metabolic traits, including elevated HbA1c, and blood cholesterol levels based on national, age-specific cut-off values, on asthma exacerbations, control, and severity, in a Danish nationwide cohort of 29,851 children aged 2-17 years with inhaled corticosteroid-treated asthma during 2015-17.
resultsAmong the 29,851 children, 1,430 had severe asthma, 4,750 had poor asthma control, and 2,353 had exacerbating asthma. Elevated LDL in the child was associated with 2.2-fold higher odds of severe asthma and elevated triglycerides with 1.5-fold higher odds of exacerbating asthma, while reduced HDL was associated with 1.5-fold higher odds of poor control. Both triglycerides and HDL were associated with 1.5-fold higher odds of exacerbating asthma. Maternal parameters including elevated LDL cholesterol, triglycerides, and HbA1C were associated with 1.2 to 1.4-fold higher odds of uncontrolled asthma in the child. Elevated paternal HbA1C was associated with exacerbating asthma.
conclusionDyslipidemia, including elevated LDL and decreased HDL, in the child and their parents was associated with high asthma burden in a Danish pediatric cohort with persistent asthma. These observations highlight the need to investigate the underlying mechanisms driven by fat metabolism that are transgenerational.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.