ReviewCardiovascular diabetology2025
Distinct types of protein modifications in diabetic endothelial dysfunction.
Review in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- HMGA1 Lactylation-Mediated Regulation of the SP1/VEGFA Axis in Pathological Angiogenesis Under Diabetic Retinopathy.Diabetes · 2026Article
- Exploring the potential targets and mechanisms of artemisinin in the treatment of diabetic kidney disease using network pharmacology and molecular docking.Functional & integrative genomics · 2026Article
- From Metabolism to Mind: The Cardio-Metabolic-Brain Axis and the Role of Insulin Resistance-A Review.Biomedicines · 2026Review
- Glutamine Substitution at LysineACS omega · 2026Article
- Molecular and cellular processes connecting type 2 diabetes to Alzheimer's disease, focusing on oxidative stress, metabolic dysfunction, and neurodegeneration.Genetics and molecular biology · 2026Article
- Investigating the Mechanistic Link Between Lactate-Induced Histone Lactylation and Cellular Senescence in Osteoarthritis Chondrocytes: Implications for Therapy.International journal of biological sciences · 2026Article
- Ubiquitination modifications as central regulators of metabolic dysfunction in type 2 diabetes mellitus.Frontiers in endocrinology · 2026Review
- Lactylation in diabetes mellitus and its complications: mechanisms of action and therapeutic potential - recent advances.Frontiers in endocrinology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Diabetes mellitus is a metabolic disorder characterized by persistent hyperglycemia. Chronic diabetes mellitus may contribute to endothelial dysfunction and result in various conditions such as diabetic retinopathy, diabetic nephropathy, neuropathy, peripheral vascular disease, and metabolic syndrome. Post-translational modifications (PTMs) refer to the chemical alterations made to amino acid residues on post-translational proteins, achieved through the addition or removal of specific functional groups. These modifications significantly influence a protein's structure and dynamics, ultimately regulating its localization, folding, interactions with other biomolecules, and overall activity, including mitochondrial function, insulin secretion, cellular development, and viability. The present review aims to provide a comprehensive overview of the different types of PTMs associated with diabetic endothelial dysfunction, including glycosylation, ubiquitination, phosphorylation, acetylation, lactylation, palmitoylation, SUMOylation, methylation, carbonylation, and other PTMs. Currently, several drugs and compounds have been found to improve endothelial cell function in diabetes mellitus by targeting PTMs. By elucidating the mechanisms through which these modifications contribute to endothelial dysfunction in diabetes, this review aspires to enhance the understanding of the condition and potentially facilitate the development of innovative therapeutic strategies aimed at addressing cardiovascular complications in individuals with diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.