Evidence map›Paper›PMID 40660315›Full record

Trial reportHead & face medicine2025

Application value of indocyanine green lymphography in the management of stage I/IIA microcystic lymphatic malformation of the tongue.

Tao Han, Lijun Shi, Songming Huang, Weimin Shen

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Head & face medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06755905 (Application Value of Indocyanine Green Lymphography in Management of Microcystic Lymphatic Malformation of the Tongue), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06755905 nacompletednot on this map

Application Value of Indocyanine Green Lymphography in Management of Microcystic Lymphatic Malformation of the Tongue

TypeinterventionalSponsorNanjing Children's HospitalRan2019 to 2024Enrolled42ConditionsLymphatic MalformationArmsICGL-guided treatment, Conventional Treatment group
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tao HanDepartment of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
Lijun ShiDepartment of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
Songming HuangDepartment of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China. smhuang@njmu.edu.cn.
Weimin ShenDepartment of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China. swmswmswm@sina.com.

Funding

Clinical Research Project of Children's Hospital of Nanjing Medical University LCYJY202305
6 · The paper itself

Abstract

backgroundThis study aims to investigate whether indocyanine green lymphography (ICGL) facilitates the effectiveness and accuracy of current management of lingual microcystic lymphatic malformation (mLM).

methodsThis retrospective included patients under 18 years old with mLM of the tongue staged I or IIA, who underwent ICGL-aided surgical resection and sclerotherapy (ICGL group) or only surgical resection and sclerotherapy (non-ICGL group) between January 2019 and June 2024. The peri- and postoperative parameters of safety and feasibility were compared between two groups.

resultsA total of 42 patients were included, 19 of whom received ICGL-guidance and the other 23 were in non-ICGL group. The comparison of baseline data between the two groups revealed no significant difference. Compared to the non-ICGL group, the ICGL group demonstrated superior efficacy (P = 0.017) and required fewer subsequent treatment sessions (P = 0.027), but had longer operative duration (P = 0.001). No significant differences were observed in terms of postoperative complications, length of hospital-stay, and follow-up period.

conclusionsICGL was associated with improved postoperative outcomes and less subsequent treatment. This technique may provide rational guidance with promising clinical prospects for management of mLM of the tongue. TRAIL REGISTRATION: This study was retrospectively registered on clinicaltrials.gov: NCT06755905, date of registration: January 20, 2025.

Indexed as

Indocyanine GreenLymphatic AbnormalitiesLymphographyTongue DiseasesAdolescentChildChild, PreschoolColoring AgentsFemaleHumansMaleRetrospective StudiesSclerotherapyTongueTreatment OutcomeColoring AgentsIndocyanine GreenChildrenIndocyanine green lymphographyMicrocystic lymphatic malformationTongue

Identifiers

PMID40660315
PMCPMC12257807

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.