Evidence map›Paper›PMID 40660422›Full record

ArticleJournal of food science2025

Whey Protein Mitigates Oxidative Stress Injury and Improves Protein Synthesis in Mouse Skeletal Muscle by Regulating the SIRT1/Nrf2/HO-1 Axis and AMPK/TSC2/mTOR/4EBP1 Pathway.

Guangqi Li, Liying Shang, Xin Wang, Lequn Zhang, Yuchu Zhao, Weifeng Ni, Xueyuan Bai, Junyi Liu

Abstract read
In one paragraph

Article in Journal of food science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guangqi LiNortheast Normal University School of Physical Education, Northeast Normal University, Changchun, Jilin, China.
Liying ShangNortheast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Xin WangNortheast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Lequn ZhangNortheast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Yuchu ZhaoNortheast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Weifeng NiNortheast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Xueyuan BaiNortheast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Junyi LiuNortheast Normal University School of Physical Education, Northeast Normal University, Changchun, Jilin, China.ORCID https://orcid.org/0000-0001-9095-8404

Funding

National key research and development progarm of China 2018YFF0300400
6 · The paper itself

Abstract

Whey protein (WP) can improve muscle mass and strength. However, its effects and underlying molecular mechanism in promoting recovery from muscle damage caused by excessive physical exercise remains unknown. Therefore, the present study aimed to investigate the therapeutic effect of WP on skeletal muscle injury caused by exogenous oxidants and excessive physical exercise and the potential underlying mechanism. An oxidative stress injury model of mouse skeletal muscle cells was established using hydrogen peroxide (H

Indexed as

Muscle, SkeletalOxidative StressWhey ProteinsAdaptor Proteins, Signal TransducingAMP-Activated Protein KinasesAnimalsCell Cycle ProteinsCell LineHeme Oxygenase-1Hydrogen PeroxideMaleMembrane ProteinsMiceMice, Inbred C57BLNF-E2-Related Factor 2Physical Conditioning, AnimalAdaptor Proteins, Signal TransducingAMP-Activated Protein KinasesCell Cycle ProteinsEif4ebp1 protein, mouseHeme Oxygenase-1Hmox1 protein, mouseHydrogen PeroxideMembrane ProteinsmTOR protein, mouseNfe2l2 protein, mouseNF-E2-Related Factor 2Sirt1 protein, mouseSirtuin 1TOR Serine-Threonine KinasesWhey ProteinsAMPK/TSC2/mTOR/4EBP1 pathwayC2C12 cellOxidative stressSIRT1/Nrf2/HO‐1 axisSkeletal muscleWhey protein

Identifiers

PMID40660422
PMCPMC12260125

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.