Evidence map›Paper›PMID 40660423›Full record

SynthesisInternational journal of dermatology2025

Regulatory T Cell Dysregulation in Vitiligo: A Meta-Analysis and Systematic Review of Immune Mechanisms and Therapeutic Perspectives.

Gabriela Lerner, Maria Nikolaou, Corinne Stoffel, Eloi Schmauch, Thomas Kündig, Thierry Passeron, Julien Seneschal, Nanja van Geel, Ulrike Held, Antonios G A Kolios

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gabriela LernerDepartment of Dermatology, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0009-0003-0152-5925
Maria NikolaouDepartment of Dermatology, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0009-0002-0654-3789
Corinne StoffelDepartment of Dermatology, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-3542-034X
Eloi SchmauchBroad Institute of MIT and Harvard, Cambridge, USA.ORCID https://orcid.org/0000-0002-2123-8777
Thomas KündigDepartment of Dermatology, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-3863-8766
Thierry PasseronDepartment of Dermatology, University Côte d'Azur. CHU Nice, Nice, France.ORCID https://orcid.org/0000-0002-0797-6570
Julien SeneschalDepartment of Dermatology and Pediatric Dermatology, National Reference Center for Rare Skin Disorders, Hôpital Saint-André, Bordeaux, France.ORCID https://orcid.org/0000-0003-1139-0908
Nanja van GeelDepartment of Dermatology, Ghent University Hospital, Ghent, Belgium.ORCID https://orcid.org/0000-0002-3249-8195
Ulrike HeldEpidemiology, Biostatistics and Prevention Institute, Department of Biostatistics, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-3105-5840
Antonios G A KoliosDepartment of Dermatology, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-3897-4578

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitiligo is an autoimmune disorder marked by the progressive loss of skin melanocytes, increasingly linked to immune dysregulation as a key driver of disease onset and progression. Regulatory T (Treg) cells are essential for maintaining immune homeostasis by suppressing autoreactive immune responses. Mounting evidence implicates functional and numerical alterations in Treg cells in the pathogenesis of vitiligo. This study reviews findings on lesional and circulating Treg cells in vitiligo patients compared to healthy controls (HCs), examining Treg cell frequency, their ability to suppress CD4

Indexed as

T-Lymphocytes, RegulatoryVitiligoCD8-Positive T-LymphocytesForkhead Transcription FactorsHumansInterleukin-10Interleukin-17Interleukin-22InterleukinsTransforming Growth Factor betaForkhead Transcription FactorsFOXP3 protein, humanInterleukin-10Interleukin-17Interleukin-22InterleukinsTransforming Growth Factor betaautoimmunitydermatologyFOXP3immune regulationimmunologyregulatory T‐cellsTreg cellsvitiligo

Identifiers

PMID40660423
PMCPMC12605810

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.