ArticleJournal of cellular and molecular medicine2025
Multi-Omics Analysis and Real-World Data Validation of Serine Metabolism-Related Genes in Colorectal Cancer.
Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Multi-Omics Analysis and Real-World Data Validation of Serine Metabolism-Related Genes in Colorectal Cancer.Journal of cellular and molecular medicine · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Serine metabolism plays a pivotal role in cancer progression by supporting essential biosynthetic pathways and energy production. Exploring the intricacies of serine metabolism in cancer may uncover novel therapeutic opportunities. This study presents a comprehensive pan-cancer analysis of serine metabolism-related genes (SMGs), with a particular emphasis on colorectal cancer (CRC), to elucidate their expression patterns, genetic alterations and clinical significance. We performed a pan-cancer analysis of SMGs using integrating transcriptomic, genomic and epigenetic data from TCGA and GTEx databases. For CRC, we performed in-depth analyses comparing expression patterns between tumour and normal tissues, examining prognostic significance and exploring associations with the tumour microenvironment (TME). The distribution patterns of SMGs within the TME were further investigated using single-cell RNA sequencing and immunohistochemistry. Key SMGs, including PHGDH, SLC1A5 and SLC38A2, were validated in two independent real-world cohorts of CRC. Pan-cancer analysis revealed that SMGs are differentially expressed across tumour types, with their dysregulation associated with copy number alterations and epigenetic modifications. In CRC, aberrant SMG expression is significantly associated with clinical outcomes, key signalling pathways and the TME. Notably, PHGDH was consistently upregulated in CRC and associated with poor prognosis, while SLC1A5 emerged as a potential biomarker for liver metastasis. This study underscores the importance of SMGs, particularly PHGDH, SLC1A5 and SLC38A2, in CRC progression and prognosis. Our findings offer valuable insights into SMGs as a potential therapeutic target and provide a foundation for developing personalised metabolic interventions in CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.