ReviewCurrent neuropharmacology2026
Targeting the cGAS-STING Pathway: Modulating Inflammation, Oxidative Stress, and Autophagy for Novel Depression Therapies.
Review in Current neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Oxidative stress in neurodegeneration: from a simple insult to a dynamic regulator.Redox report : communications in free radical research · 2026Review
- Spotlight on cGAS-STING: role in disease pathogenesis and therapeutic potential.Molecular biomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The pathological mechanisms underlying depression, a prevalent mental disorder, remain only partially elucidated despite extensive research efforts. Recent advancements have underscored the pivotal roles of multiple biological processes in the onset and progression of depression, including inflammation, oxidative stress, and autophagy. Inflammation is associated with the disruption of neurotransmitter systems and neural plasticity, whereas oxidative stress contributes to neuronal damage and impaired brain function. Moreover, moderate autophagy is essential for maintaining neuronal health. Dysregulation of autophagy may lead to the accumulation of damaged proteins and organelles, which can exacerbate depressive symptoms. Among the various molecular pathways involved, the cGAS-STING signalling pathway has emerged as a key regulator of these processes. Traditionally known for its role in detecting cytosolic DNA and initiating innate immune defences against pathogens, the cGAS-STING pathway has recently been implicated in regulating inflammatory responses, oxidative stress levels, and autophagy in the central nervous system. This dual function positions the cGAS-STING pathway as a potential link between immune dysregulation and the neurobiological foundations of depression. This paper offers a systematic overview of existing studies on the role of the cGAS-STING pathway in inflammation, oxidative stress, and autophagy within the central nervous system, particularly in the context of depression. The review reveals how modulation of the cGAS-STING pathway may influence these critical biological processes and thereby ameliorate depressive symptoms. Furthermore, the review discusses the therapeutic potential of targeting the cGAS-STING pathway and offers promising research directions. Ultimately, this paper aims to provide novel insights and approaches for developing more effective treatments for depression.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.