Evidence map›Paper›PMID 40660680›Full record

ReviewClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2025

Cue-induced Magnetic Resonance Spectroscopy of Glutamate in Addiction Research: Current Evidence, Pros, and Cons.

Muhammad Abdullah, Shih-Hsien Lin, Li-Chung Huang, Muhammad Imran Khan, Chun-Chia Kung, Yen Kuang Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Muhammad AbdullahTaiwan International Graduate Program in Interdisciplinary Neuroscience, National Cheng Kung University and Academia Sinica, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-1822-4152
Shih-Hsien LinClinical Medicine Research Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0001-9904-8300
Li-Chung HuangInstitute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0009-0009-9077-941X
Muhammad Imran KhanDepartment of Biomedical Science, Pak-Austria Fachhochschule: Institute of Applied Science and Technology, Mang Haripur, Pakistan.ORCID https://orcid.org/0000-0003-4777-5084
Chun-Chia KungDepartment of Psychology, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-4362-7837
Yen Kuang YangDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0001-9355-9636

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cues, which induce craving, and may lead to relapse, are an important paradigm for addiction research. Visual cues related to addictive substances trigger powerful neurophysiological responses in the brains of addicts, leading to craving. However, the molecular mechanisms underlying these neurophysiological responses remain incompletely understood. While the role of dopamine in cue-induced phenomena has been extensively studied, the contribution of glutamate, a major excitatory neurotransmitter and a key player in cue-associated phenomena as proposed by animal studies, is less explored in humans. Functional magnetic resonance spectroscopy (fMRS) is a promising tool for investigating glutamatergic modulations in tasks. This review aims to evaluate the potential of fMRS in explaining the dynamics of glutamate during cue-induced phenomena in drug addiction. We discuss the clinical implications, strengths, and limitations of fMRS in this context and propose directions for future research.

Indexed as

Clinical researchCuesFunctional magnetic resonance spectroscopyGlutamateSubstance-related disorders

Identifiers

PMID40660680
PMCPMC12264660

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.