ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2025
Tight Junction Proteins and Blood-brain Barrier Integrity in Pediatric Obsessive-compulsive Disorder: A Study on Claudin-5, Claudin-12, Occludin, Tricellulin, and Angulin-1.
Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Impact of Obstructive Sleep Apnea on Blood-Brain Barrier Permeability and Membrane Proteins.International journal of molecular sciences · 2026Review
- Hippocampal neuroinflammation and altered peripheral neurobiological protein profile in experimental arthritis and systemic juvenile idiopathic arthritis.EBioMedicine · 2026Article
- Relationship of Serum Tricellulin, MarvelD3, and Tumor Necrosis Factor-Alpha Levels With Obsessive-Compulsive Disorder Severity in Children and Adolescents.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2026Article
- Tubuloside B ameliorates blood-brain barrier disruption and cognitive deficits after cerebral ischemia by inhibiting TRIC protein ubiquitination and degradation.Journal of neuroinflammation · 2025Article
- The Breakdown of Neurovascular Barriers: Molecular Mechanisms of Tight Junction Dysfunction.Molecular neurobiology · 2025Review
- Claudin 5 Across the Vascular Landscape: From Blood-Tissue Barrier Regulation to Disease Mechanisms.Cells · 2025Review
- Claudin-5 and inflammatory biomarkers in panic disorder: a 6-week follow-up study.Frontiers in psychiatry · 2025Article
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4 authors.
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Abstract
Objective: Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by the presence of obsessions and/or compulsions that cause significant distress and functional impairment. Despite extensive research, its etiopathogenesis remains incompletely understood. Recent evidence suggests that dysfunction in tight junctions may contribute to the pathophysiology of various psychiatric disorders. Tight junction proteins play a crucial role in maintaining blood-brain barrier integrity and regulating neuronal signaling. This study aims to investigate the involvement of tight junction proteins in the etiopathogenesis of OCD, providing new insights into their potential role in the disorder's neurobiological mechanisms. Methods: A total of 41 medication-free children and adolescents with OCD and 41 healthy controls were included in this study. The participants filled out self-report scales to determine various psychological variables. Blood samples were collected from all participants to measure the levels of claudin-5, claudin-12, occludin, angulin-1, and tricellulin. Results: The levels of claudin-5, claudin-12, occludin, and tricellulin were significantly higher in the OCD group compared to the control group. However, there was no significant difference in angulin-1 levels between the groups. Conclusion: Our findings indicate that claudin-5, claudin-12, occludin, and tricellulin levels differ between individuals with OCD and healthy controls. These results suggest that tight junction proteins may contribute to the etiopathogenesis of OCD. Further research is needed to better understand the relationship between OCD and tight junction proteins.
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