Directed cell-type recruitment during consolidation of a remote memory.

Zachary Zeidler, Abigail L Yu, Moonkyu Patrick Seong, Rio Hundley, Laura A DeNardo

Abstract readPreprint

In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zachary ZeidlerDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-6539-4360

Abigail L YuDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Moonkyu Patrick SeongDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Rio HundleyDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Laura A DeNardoDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Funding

Role of prefrontal dopamine circuits in threat avoidance learningR01MH137461 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Laura Anne DeNardo, Scott Allen Wilke · 2024 to 2026

$2.2M

Reorganization of cortical memory ensembles across timeF32MH133387 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZEIDLER, ZACHARY E · 2023 to 2025

$192k

NIMH NIH HHS F32 MH133387NIMH NIH HHS R01 MH137461

6 · The paper itself

Abstract

Memories are consolidated into a distributed neocortical network for long-term storage. Long-term memory retrieval relies on cells that are active during learning and undergo necessary plasticity. However, remote memory retrieval activates a broader circuit, with learning-activated cells representing only a small subset. What are the rules and cell-types governing memory trace reorganization? We identified a class of prefrontal projection neurons that are gradually recruited to a memory trace through synaptic activity of learning-activated cells. This population, which projects to the temporal association area (TEa), progressively strengthens its encoding of memory-induced behaviors, mirroring increases in TEa activity. Notably, the prefrontal-TEa pathway is required for remote but not recent memory retrieval. Our findings reveal a cell type-specific mechanism underlying memory trace reorganization during consolidation.

Identifiers

PMID40661376

DOI10.1101/2025.06.13.659562

PMCPMC12259166

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.