ArticlebioRxiv : the preprint server for biology2025
Identification and Validation of a Previously Missed Mutational Signature in Colorectal Cancer.
Mariya Kazachkova, Burçak Otlu, Marcos Díaz-Gay, Ammal Abbasi, Sarah Moody, Sandra Perdomo, David C Wedge, Paul Brennan, Michael R Stratton, Ludmil B Alexandrov
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Mariya KazachkovaBiomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA.
Burçak OtluDepartment of Health Informatics, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey.
Marcos Díaz-GayDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Ammal AbbasiDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Sandra PerdomoGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
David C WedgeManchester Cancer Research Centre, University of Manchester, Manchester, UK.
Paul BrennanGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Michael R StrattonCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Ludmil B AlexandrovBiomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3596-4515 Funding
Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)P01CA281819 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Karin · 2024 to 2026
$9.2MPredoctoral and Postdoctoral Training in Cancer Cell BiologyT32CA067754 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEAN Y.J. WANG · 1995 to 2026
$6.5MDetecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4MMapping immuno-genomic drivers of the head and neck precancer invasive-disease transitionU01CA290479 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Jorge Silvio Gutkind · 2023 to 2026
$3.1MComprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2MUnderstanding the origins of the mutational landscape in cancerR01ES036931 · NIEHS · UNIV OF ARKANSAS FOR MED SCIS · PI Ludmil B Alexandrov, Gunnar Boysen · 2025 to 2026
$1.5MExploring the Impact of Base Deaminase Deregulation on Precancer EvolutionR01CA296974 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Catriona Helen Macleod Jamieson · 2025 to 2026
$890kNCI NIH HHS P01 CA281819NCI NIH HHS R01 CA269919NCI NIH HHS R01 CA296974NCI NIH HHS T32 CA067754NCI NIH HHS U01 CA290479NIEHS NIH HHS R01 ES032547NIEHS NIH HHS R01 ES036931Wellcome Trust
6 · The paper itselfAbstract
Mutational signature analysis has greatly enhanced our understanding of the mutagenic processes found in cancer and normal tissues. As part of a recent study, we analyzed 802 treatment-naïve, microsatellite-stable colorectal cancers (CRC) and identified a
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PMID40661437
PMCPMC12258970
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