Evidence map›Paper›PMID 40661574›Full record

ArticlebioRxiv : the preprint server for biology2025

Error encoding in human speech motor cortex.

Xianda Hou, Carrina Iacobacci, Nicholas S Card, Maitreyee Wairagkar, Tyler Singer-Clark, Erin M Kunz, Chaofei Fan, Foram Kamdar, Nick Hahn, Leigh R Hochberg and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xianda HouDepartment of Neurological Surgery, University of California, Davis, Davis, CA, USA.ORCID 0009-0002-2066-8561
Carrina IacobacciDepartment of Neurological Surgery, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-1690-6272
Nicholas S CardDepartment of Neurological Surgery, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-6858-268X
Maitreyee WairagkarDepartment of Neurological Surgery, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-9546-2843
Tyler Singer-ClarkDepartment of Neurological Surgery, University of California, Davis, Davis, CA, USA.ORCID 0000-0001-8636-5075
Erin M KunzDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.ORCID 0009-0003-5246-6937
Chaofei FanDepartment of Computer Science, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2549-548X
Foram KamdarDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0009-0000-2734-3247
Nick HahnDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0009-0004-1663-2018
Leigh R HochbergSchool of Engineering and Carney Institute for Brain Sciences, Brown University, Providence, RI, USA.ORCID 0000-0003-0261-2273
Jaimie M HendersonDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3276-2267
Francis R WillettDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2652-8511
David M BrandmanDepartment of Neurological Surgery, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-3224-7019
Sergey D StaviskyDepartment of Neurological Surgery, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-5238-0573

Funding

Understanding and restoring speech production using an intracortical brain-computer interfaceDP2DC021055 · NIDCD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI STAVISKY, SERGEY · 2022 to 2025
$2.3M
NIDCD NIH HHS DP2 DC021055
6 · The paper itself

Abstract

Humans monitor their actions, including detecting errors during speech production. This self-monitoring capability also enables speech neuroprosthesis users to recognize mistakes in decoded output upon receiving visual or auditory feedback. However, it remains unknown whether neural activity related to error detection is present in the speech motor cortex. In this study, we demonstrate the existence of neural error signals in speech motor cortex firing rates during intracortical brain-to-text speech neuroprosthesis use. This activity could be decoded to enable the neuroprosthesis to identify its own errors with up to 86% accuracy. Additionally, we observed distinct neural patterns associated with specific types of mistakes, such as phonemic or semantic differences between the person's intended and displayed words. These findings reveal how feedback errors are represented within the speech motor cortex, and suggest strategies for leveraging these additional cognitive signals to improve neuroprostheses.

Identifiers

PMID40661574
PMCPMC12259010

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.