ReviewCureus2025
Cardiovascular-Renal-Hepatic-Metabolic Syndrome: Interlinked Pathophysiology and Integrated Management Approach.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Metabolic disorder-MASLD-cardiovascular disease-kidney disease (MMCK) syndrome: an expansion of the Cardiovascular-Kidney-Metabolic (CKM) framework.Cardiovascular diabetology. Endocrinology reports · 2026Review
- Butyrate and Butyrate-Producing Bacteria in Cardiovascular-Kidney-Metabolic Syndrome.Antioxidants (Basel, Switzerland) · 2026Review
- Article
- [Advances in research on metabolic associated fatty liver disease in 2025].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- Metabolic Dysfunction at the Core: Revisiting the Overlap of Cardiovascular, Renal, Hepatic, and Endocrine Disorders.Life (Basel, Switzerland) · 2026Review
- Association between vascular overload index and arterial stiffness: a secondary analysis of a nationwide cross-sectional study in Japan.European journal of medical research · 2025Article
- Periodontal Medicine: The Past, the Present, the Future.Journal of periodontal research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interdisciplinary research has revealed that heart, kidney, liver, and metabolic diseases share interlinked pathological mechanisms, including inflammation, oxidative stress, insulin resistance, and endothelial health issues. However, integrated care for these diseases is challenging due to different symptoms, diagnostic rules, and treatment options. The review aims to study the common mechanisms behind cardiovascular-renal-hepatic-metabolic syndrome and explore ways to coordinate management. When these systems work poorly together, damage can form a vicious cycle, increasing hypertension, chronic kidney disease, non-alcoholic fatty liver disease, and metabolic syndrome. Changes in medicine, daily lifestyle, and drugs can interrupt the pathological cascade. However, clinical practice is hindered by patient presentations, lack of teamwork across healthcare specialties, and incomplete therapy plans. Gut-organ axis dysfunction and inflammation play a significant role in multiple organ diseases, and prompt risk assessment and early intervention can prevent heart damage.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.