ReviewJournal of diabetes and metabolic disorders2025
Propolis supplementation improves cardiometabolic health in patients with type 2 diabetes mellitus: findings from a GRADE-assessed systematic review and meta-analysis of RCTs.
Review in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Ginger Supplementation and Blood Pressure in Adults: A GRADE-Based Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Pooled it
- Effects of Probiotics and Synbiotics Supplementation on Blood Pressure in Adults with Prediabetes and Type 2 Diabetes Mellitus: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis.Probiotics and antimicrobial proteins · 2026Pooled it
- Therapeutic Potential of Water-Based Anatolian Propolis Extract Against CAF Diet-Induced Obesity and Its Metabolic Complications.Food science & nutrition · 2026Article
- Effects of Walnut Consumption on Blood Lipid Profile and Apolipoproteins in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis of 49 Randomized Controlled Trials.Food science & nutrition · 2026Review
- Effects of propolis supplementation on blood glucose and lipid profiles in individuals with metabolic syndrome and type 2 diabetes: a systematic review and meta-analysis.Clinical nutrition research · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aim: Diabetes is a common metabolic disorder associated with cardiometabolic complications. Propolis, a natural resinous compound, has shown potential benefits in improving metabolism. However, existing evidence remains inconsistent and fragmented. This study aims to systematically review and meta-analyze to evaluate the impact of propolis supplementation on cardiometabolic indices in patients with Type 2 diabetes mellitus (T2DM). Method: A comprehensive search was performed in online major databases up to April 2025 to identify eligible randomized controlled trials (RCTs). Studies meeting the inclusion criteria were systematically reviewed and analyzed for relevant outcomes. A random-effects model was used to calculate pooled weighted mean differences (WMDs) with 95% confidence intervals (CIs), taking into account study heterogeneity. Results: The pooled analysis of 13 RCTs revealed that propolis supplementation in individuals with T2DM led to a significant reduction in fasting plasma glucose (WMD: -15.29 mg/dL), 2-hour postprandial glucose (WMD: -35.41 mg/dL), HbA1c (WMD= -0.58%), fasting insulin (WMD: -1.93 µU/mL), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (WMD: -0.99), low-density lipoprotein cholesterol (LDL-C) (WMD: -11.47 mg/dL), interleukin 6 (IL-6) (WMD: 1.52 pg/mL), tumor necrosis factor-alpha (TNF-α) (WMD: 2.28 pg/mL), and body weight (WMD: 2.09 kg). In contrast, the meta-analysis revealed no significant changes in triglycerides (TG) ( Conclusion: Propolis supplementation may serve as a beneficial adjunct therapy for patients with T2DM, showing significant improvements in blood glycemic markers, serum lipid profile, inflammation, and body weight. The overall findings support the use of propolis as a promising complementary approach to enhance cardiometabolic health in T2DM. Clinical trial number: Not applicable. Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-025-01682-w.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.