Evidence map›Paper›PMID 40662251›Full record

ArticleAdvanced healthcare materials2025

Biomimetic Scaffolds with Dual Gradients of Biological Effectors for Tendon-to-Bone Repair.

Min Hao, Yidan Chen, Stavros Thomopoulos, Younan Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Min HaoThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.ORCID https://orcid.org/0009-0006-3517-3392
Yidan ChenSchool of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.ORCID https://orcid.org/0000-0001-9472-4138
Stavros ThomopoulosDepartment of Orthopedic Surgery and Department of Biomedical Engineering, Columbia University, New York, NY, 10032, USA.
Younan XiaThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.ORCID https://orcid.org/0000-0003-2431-7048

Funding

Biomimetic approaches for enthesis tissue engineeringR01AR080924 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stavros Thomopoulos, YOUNAN XIA · 2023 to 2026
$1.9M
Georgia Institute of TechnologyNational Science Foundation ECCS-2025462NIAMS NIH HHS R01 AR080924NIH HHS R01 AR080924
6 · The paper itself

Abstract

Due to the complexspatial gradients in composition and structure at the native tendon-to-bone attachment, it remains a clinical challenge to repair rotator cuff tears. Herein, we describe a biomimetic scaffold with dual gradients in osteogenic and tendon enthesis effectors to regulate the graded differentiation of stem cells for tendon-to-bone repair. Funnel-shaped microchannels prompted stem cells to rapidly infiltrate into the scaffold to experience the dual gradients in biological effectors along the walls of each microchannel. The graded distributions of two different effectors-hydroxyapatite nanorods and hedgehog agonist-worked synergistically to promote the differentiation of stem cells into osteoblasts, chondrocytes, and tenocytes, reproducing the cell phenotypes present in the natural tendon enthesis. The new scaffold offers a versatile platform to address key requirements for successful repair/regeneration of the tendon-to-bone attachment while also presenting an innovative strategy for the repair of connective tissue interfaces in general.

Indexed as

Biomimetic MaterialsMesenchymal Stem CellsRotator Cuff InjuriesTissue ScaffoldsBone and BonesCell DifferentiationCells, CulturedChondrocytesDurapatiteHedgehog ProteinsHumansNanotubesOsteoblastsOsteogenesisRotator CuffTenocytesDurapatiteHedgehog Proteinsgraded differentiationhedgehog agonistshydroxyapatite nanorodsinterfacial diffusionstem cells

Identifiers

PMID40662251
PMCPMC12494179

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.