Evidence map›Paper›PMID 40662940›Full record

ArticleeLife2025

Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention.

Alisa Sukhina, Clemence Queriault, Saptarshi Roy, Elise Hall, Kelly Rome, Muskaan Aggarwal, Elizabeth Nunn, Ashley Weiss, Janet Nguyen, F Chris Bennett and 1 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Alisa SukhinaDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, United States.
Clemence QueriaultDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, United States.
Saptarshi RoyDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, United States.
Elise HallDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, United States.
Kelly RomeDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, United States.
Muskaan AggarwalDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Elizabeth NunnDepartment of Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.
Ashley WeissDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, United States.
Janet NguyenDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, United States.
F Chris BennettDepartment of Psychiatry, Perelman School of Medicine , University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0000-0003-2570-0620
Will BailisDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, United States.ORCID https://orcid.org/0000-0001-9420-6250

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS J EPSTEIN · 1986 to 2026
$48.3M
IMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1M
Stress-modified growth signaling in dynamic nutrient environmentsR35GM138085 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Will H. Bailis · 2020 to 2026
$2.7M
NCI NIH HHS T32 CA009140NCI NIH HHS T32CA009140NIDDK NIH HHS P30 DK019525NIGMS NIH HHS R35 GM138085NIGMS NIH HHS R35GM138085
6 · The paper itself

Abstract

Undernutrition remains a major global health crisis, with nearly 1 billion people experiencing severe food insecurity. Malnourished individuals are especially vulnerable to infectious diseases, which is the leading cause of morbidity and mortality for this population. Despite the known link between undernutrition and infection susceptibility, the mechanisms remain poorly understood, and it is unclear whether refeeding can reverse nutritionally acquired immunodeficiency. Here, we investigate how malnutrition leads to immune dysfunction and the ability of refeeding to repair it. Malnourished mice show an inability to control sublethal

Indexed as

ListeriosisMalnutritionMyelopoiesisAnimalsDisease SusceptibilityListeria monocytogenesMiceMice, Inbred C57BLMonocytesNeutrophilsdietimmunodeficiencyimmunologyinfectious diseaseinflammationmalnutritionmicrobiologymousemyelopoiesisneutrophilrefeeding

Identifiers

PMID40662940
PMCPMC12263150

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.