ArticleCancer control : journal of the Moffitt Cancer Center
Prognostic and Predictive Value of Pan-Immune Inflammation Value in Rectal Cancer Patients Treated With Neoadjuvant Therapy.
Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Prognostic significance of integrating pretreatment biopsy-derived Immunoscore and Pan-Immune-Inflammation value in locally advanced rectal cancer after neoadjuvant chemoradiotherapy.Clinical and translational radiation oncology · 2026Article
- Mitochondrial fitness in circulating T cells predicts neoadjuvant therapy response in locally advanced colorectal cancer.Gastroenterology report · 2026Article
- Prognostic value of combining nutritional inflammatory index trajectories and tumor characteristics in cervical cancer.BMC women's health · 2025Article
- Prognostic Value of the Cancer Inflammation Prognostic Index (CIPI) in De Novo Metastatic Colon Cancer: A Multicenter Retrospective Cohort Study.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
3 authors.
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Abstract
IntroductionPredicting prognosis before treatment in rectal cancer patients undergoing neoadjuvant therapy is essential for effective treatment strategy selection. This study evaluates the prognostic impact of the pretreatment pan-immune-inflammation value (PIV) on pathological response, local control, and overall survival.MethodsWe included 126 patients who received neoadjuvant treatment for rectal cancer from November 2020 to May 2024. This study was conducted retrospectively. PIV was calculated as (neutrophil count × platelet count × monocyte count)/lymphocyte count, with an optimal threshold identified at 475. Patients were categorized into low (PIV < 475) and high (PIV ≥ 475) groups. Pathological responses were analyzed using the chi-square test, while survival rates were assessed with the Kaplan-Meier method and log-rank tests. Cox regression analysis examined the influence of variables on outcomes.ResultsThe high PIV group had a significantly higher prevalence of N2 disease (33.3% vs 13.7%,
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