Evidence map›Paper›PMID 40663270›Full record

ReviewMolecular neurobiology2025

Ubiquitination in the Nervous System: From Molecular Mechanisms to Disease Implications.

Yan Xue, Xiaoshan Liu, Xiao Chen, Shengnan Zhang, Wu Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yan Xue *School of Pharmacy, Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning , Hubei, 437000, China.
Xiaoshan Liu *School of Pharmacy, Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning , Hubei, 437000, China.
Xiao Chen *School of Pharmacy, Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning , Hubei, 437000, China.
Shengnan ZhangSchool of Resource and Environmental Sciences and Engineering, Hubei University of Science and Technology, Xianning , Hubei, 437000, China.
Wu LiuSchool of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, No. 88 Xianning Avenue, Xianning , Hubei, 437000, China. lw463684057@163.com.

Funding

Doctoral Foundation of Hubei University of Science and Technology BK202440Hubei Provincial Natural Science Foundation and Xianning Innovation and development project 2025AFD403National Natural Science Foundation of China 42407042Scientific Innovation Team of Hubei University of Science and Technology 2023T11
6 · The paper itself

Abstract

The ubiquitin‒proteasome system (UPS) comprises ubiquitin, various enzymes, and the proteasome, which are collectively responsible for selectively regulating protein degradation within the human body. Ubiquitination plays a crucial role in various physiological and pathological processes of the nervous system. In neurons, ubiquitination influences synaptic transmission, neural network formation, and mitochondrial homeostasis. E3 ubiquitin ligases (E3s) such as ubiquitin-protein ligase E3A (UBE3A), HUWE1, and Parkin, along with deubiquitinating enzymes (DUBs) such as USP9X (ubiquitin specific peptidase 9, X-linked) and OTUD5, are vital for neural development and functional maintenance. The dysregulation of ubiquitination is closely associated with neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). A comprehensive understanding of the functions of ubiquitination in the nervous system and an in-depth exploration of its mechanisms in neural development and disease progression may reveal potential targets and therapeutic strategies for treating neurodegenerative disorders.

Indexed as

Nervous SystemNeurodegenerative DiseasesUbiquitinationAnimalsHumansProteasome Endopeptidase ComplexUbiquitinUbiquitin-Protein LigasesProteasome Endopeptidase ComplexUbiquitinUbiquitin-Protein LigasesDeubiquitinasesE3 ubiquitin ligasesNeural developmentNeurodegenerative diseasesUbiquitination

Identifiers

PMID40663270

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.