ReviewMethods in molecular biology (Clifton, N.J.)2025
DNA-Encoded Peptide Library Synthesis and Applications, a Mini-Review.
Review in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA-encoded chemical libraries (DECLs) are an innovative technology that combines molecular biology and combinatorial chemistry to create and screen vast libraries of small molecules and peptides. DECLs, including DNA-encoded peptide libraries (DEPLs), leverage DNA as a molecular barcode, enabling the identification of binders through affinity selection and sequencing. Advanced techniques, such as DNA-encoded self-assembled chemical libraries (DESACLs), enhance library diversity by using DNA hybridization and self-assembly to produce dual pharmacophores, significantly advancing fragment-based drug discovery.The modular nature of DESACLs allows for dynamic assembly and combinatorial expansion, generating libraries with millions of combinations. This approach supports drug discovery by targeting complex biological interactions, such as protein-protein interfaces and provides a platform for molecular diagnostics.
Indexed as
Identifiers
40663320What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.