ReviewEuropean heart journal2025
Circadian rhythms in cardiovascular disease.
Review in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models.BMC medicine · 2026Pooled it
- Sleep-Aligned Extended Overnight Fasting Improves Nighttime and Daytime Cardiometabolic Function.Arteriosclerosis, thrombosis, and vascular biology · 2026Trial
- Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Social jet lag is associated with incident cardiovascular disease independent of sleep duration and cardiac genetic risk.Journal of internal medicine · 2026Article
- Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications.Neuroprotection (Chichester, England) · 2026Review
- Short-Chain Fatty Acids in Heart Failure with Preserved Ejection Fraction: Pathophysiological Roles and Therapeutic Potential.International journal of molecular sciences · 2026Review
- Sleep loss as a cardiometabolic risk factor: a narrative review of clinical and public health implications.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Review
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Cardio Protective Role of Graphene-based FeCell biochemistry and biophysics · 2026Article
- Machine learning-based stratification of chagas heart failure severity using ECG power spectral biomarkers.Medical & biological engineering & computing · 2026Article
- The biological clock in parkinson's disease: mechanisms and chronotherapy.NPJ Parkinson's disease · 2026Review
- The association of time-restricted eating and indices of organ-specific aging in relation to metabolic health and obesity.NPJ science of food · 2026Article
- Circadian Activity Disruption in Cardiac Remodeling Patients Underlies Autonomic Dysfunction in Heart Failure.Biomedicines · 2026Article
- Community-acquired pneumonia alters circadian regulation of cardiac electrophysiology in children.European journal of pediatrics · 2026Article
- Characterizing Infiltrating Macrophages in Intracranial Aneurysm with IA Animal Models and Spatial Transcriptomics.Translational stroke research · 2026Review
- The Association Between Food Insecurity and Adverse Health Outcomes in Children and Adolescents: An Umbrella Review.Food science & nutrition · 2026Review
- The clinical value of circadian biofeedback in chronic heart failure.European heart journal. Digital health · 2026Article
- Out-of-Hospital Cardiac Arrest in Southern Italy: A Retrospective Analysis of 11,653 Cases.Journal of cardiovascular development and disease · 2026Article
- Association between nocturnal ozone enhancement and daily cardiovascular mortality: A multi-city study in China.Eco-Environment & Health · 2026Article
- Adipose Tissue Circadian Dysregulation Beyond BMI: Implications for Cardiometabolic Risk and Cardiovascular Disease.Life (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Circadian rhythms, controlled by the suprachiasmatic nucleus and peripheral clocks, regulate 24-h cycles in biological processes such as the cardiovascular system. Circadian rhythms influence autonomic balance, with parasympathetic dominance during sleep supporting cardiac recovery and sympathetic activation during the day supporting circulatory demand. Congruent with systemic and cellular circadian rhythmicity, 24-h patterns arise in the pathophysiology of cardiovascular diseases, including ischaemic heart disease, heart failure, and arrhythmias. Daily variations influence the timing and outcome of myocardial infarction, with studies reporting patterns in infarct size depending on the time of onset. Similar daily patterns are observed in cardio- and cerebrovascular complications. In heart failure, circadian rhythms are dampened but remain intact, suggesting the potential for incorporating timing in diagnostics and therapies. Sudden cardiac death follows a distinct pattern, with a higher incidence in the morning. Atrial fibrillation onset, on the other hand, occurs more frequently at night. Risk factors and modifiers, such as physiological, psychological, lifestyle, and environmental factors and comorbidities interact with circadian rhythms, thereby impacting cellular pathomechanisms and development of cardiovascular health and disease. Chronotherapy, which aligns treatments with circadian rhythms, has demonstrated potential for improving the efficacy of cardiovascular therapies. This review examines the influence of circadian rhythms on cardiovascular health in the context of specific cardiac diseases and risk factors, and it highlights the therapeutic opportunities informed by circadian patterns.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.