ArticleCell reports2025
A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- A microbiome-derived olfactory signal regulates inter-male aggression and social dominance in mice.Current biology : CB · 2026Article
- The Olfr151 Odorant Receptor Gene is Resistant to Activation in Embryonic Stem Cells.bioRxiv : the preprint server for biology · 2026Article
- Determinants of odorant receptor transcription and gene choice.Chemical senses · 2025Review
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Authors and funding
9 authors.
Funding
Abstract
In the mouse, more than 1,100 odorant receptors (ORs) are expressed in a monogenic and monoallelic fashion, referred to as singular gene expression. Here, we utilize multimers of a naturally occurring 21-bp (x21) OR enhancer and radically increase the number of olfactory sensory neurons (OSNs) choosing an OR transgene that is normally expressed by class II cell types. Surprisingly, hundreds of ORs derived from class I, class II, and trace amine-associated receptor (TAAR) cell types have reduced expression and are replaced by the OR transgene expression, leading to novel glomeruli formed in three segregating domains of glomeruli on the olfactory bulb: DI (class I), DII (class II), and DIII (TAAR). The reduction of expression across distinct cell types that were thought to have distinct mechanisms of singular gene choice in favor of the expression of the x21-OR transgene suggests that a common mechanism of singular gene choice is present for all OR-expressing OSNs.
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Registered trials
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