ArticleCell metabolism2025
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication.
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Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
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Who cites it
12 citing papers in PubMed.
- Somatostatin receptors shape insulin and glucagon output within the pancreatic islet in mice through direct and paracrine effects.Diabetologia · 2026Article
- Adaptive islet biology and comprehensive incretin physiology: Emerging perspectives from Asia and Europe.Journal of diabetes investigation · 2026Article
- Pancreatic Islet Cell Crosstalk: Insight Into α-/β-Cell Compensatory Mechanisms.Comprehensive Physiology · 2026Article
- Primary cilia regulate GLP-1 signaling in pancreatic β cells.Molecular metabolism · 2026Article
- Article
- Survodutide acts through circumventricular organs in the brain and activates neuronal regions associated with appetite regulation.Molecular metabolism · 2026Article
- Gαs defines the fundamental coupling mechanism of insulin secretion.Journal of diabetes investigation · 2026Article
- Antecedent hypoglycaemia impairs glucagon secretion by enhancing somatostatin-mediated negative feedback control.Nature metabolism · 2026Article
- Somatostatin Receptors Shape Insulin and Glucagon Output within the Pancreatic Islet through Direct and Paracrine Effects.bioRxiv : the preprint server for biology · 2025Article
- Exploring Sex-Specific Mechanisms in Type 2 Diabetes Mellitus by Single-Cell Analysis in Pancreatic Islets.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- β-cell heterogeneity and molecular plasticity in type 2 diabetes: multi-omics perspectives and the role of gut microbiota.Frontiers in cell and developmental biology · 2025Review
- Research progress on oral glucagon-like peptide-1 receptor agonists in the treatment of diabetes mellitus type 2.Frontiers in molecular biosciences · 2025Review
Corrections and comments
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Authors and funding
22 authors.
Jason C L TongOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Charlotte Frazer-MorrisOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Ali H ShillehOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Katrina ViloriaOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Anne de BrayOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Adithya Muraleedaran NairOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Paul R V JohnsonOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Rebecca SpiersOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Ahmad KobiitaNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Oladapo E OlaniruDepartment of Diabetes, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Shanta J PersaudDepartment of Diabetes, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Robert HauffeInstitute of Nutritional Science, Department of Molecular and Experimental Nutritional Medicine, University of Potsdam, 14558 Nuthetal, Germany.
André KleinriddersInstitute of Nutritional Science, Department of Molecular and Experimental Nutritional Medicine, University of Potsdam, 14558 Nuthetal, Germany.
Carsten SchultzDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L334, Portland, OR 97239, USA.
C Bruce VerchereDepartments of Surgery and Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, BC Children's Hospital Research Institute and Centre for Molecular Medicine and Therapeutics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada.
Canqi CuiDuke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
Jonathan E CampbellDuke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA; Department of Medicine, Duke University, Durham, NC 27710, USA; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Malgorzata CyrankaNovo Nordisk Research Centre Oxford, Innovation Building, Oxford, UK.
Alexey EpanchintsevNovo Nordisk Research Centre Oxford, Innovation Building, Oxford, UK.
Carina ÄmmäläNovo Nordisk Research Centre Oxford, Innovation Building, Oxford, UK.
Johannes BroichhagenLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Straße 10, 13125 Berlin, Germany.
David J HodsonOxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Electronic address: david.hodson@ocdem.ox.ac.uk.
Funding
ENGINEERED GLUCOSE METABOLISM IN INSULIN-SECRETING CELLSR01DK046492 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI NEWGARD, CHRISTOPHER B · 1993 to 2025
$7.8MEngineered Glucose Metabolism in Insulin Secreting CellsR37DK046492 · NIDDK · DUKE UNIVERSITY · PI NEWGARD, CHRISTOPHER B · 2003 to 2010
$3.5MNovel metabolic actions of GIPR01DK125353 · NIDDK · DUKE UNIVERSITY · PI CAMPBELL, JONATHAN E, D'ALESSIO, DAVID A. · 2020 to 2024
$2.1MAlpha- to Beta-Cell Communication in Health and DiseaseR01DK142423 · NIDDK · DUKE UNIVERSITY · PI Jonathan E Campbell, DAVID A. D'ALESSIO · 2024 to 2026
$1.9MMetabolic Actions of GlucagonR01DK141090 · NIDDK · DUKE UNIVERSITY · PI Jonathan E Campbell, DAVID A. D'ALESSIO · 2025 to 2026
$1.6MRegulation of Adipose Tissue Plasticity by Pericyte GIPRR01DK143978 · NIDDK · DUKE UNIVERSITY · PI Jonathan E Campbell, Rana K Gupta · 2025 to 2026
$1.6MNIDDK NIH HHS R01 DK046492NIDDK NIH HHS R01 DK125353NIDDK NIH HHS R01 DK141090NIDDK NIH HHS R01 DK142423NIDDK NIH HHS R01 DK143978NIDDK NIH HHS R37 DK046492
Abstract
Pancreatic alpha cells modulate beta cell function in a paracrine manner through the release of glucagon. However, the detailed molecular architecture underlying alpha-to-beta cell regulation remains poorly characterized. Here, we show that the glucagon-like peptide-1 receptor (GLP1R) is enriched as nanodomains on beta cell membranes that contact alpha cells, in keeping with increased single-molecule transcript expression. At low glucose, beta cells next to alpha cells directly sense micromolar glucagon release by pre-internalizing GLP1R. Pre-internalized GLP1R is associated with earlier beta cell Ca
Indexed as
Cell CommunicationGlucagon-Like Peptide-1 ReceptorGlucagon-Secreting CellsInsulin-Secreting CellsAnimalsCalciumGlucagonGlucoseInsulinInsulin SecretionMaleMiceMice, Inbred C57BLRatsSignal TransductionCalciumGlp1r protein, mouseGlucagonGlucagon-Like Peptide-1 ReceptorGlucoseInsulinalpha cellbeta cellCa(2+)diabetesGLP1Rglucagoninsulinisletpancreassignaling
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.