ReviewProceedings. Biological sciences2025
Biophysical properties of the membrane influence spike initiation dynamics and neuronal excitability: a focus on Kv1 channels in myelinated axons.
Review in Proceedings. Biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The Axon as a Self-Modifying Computational System: Autonomous Inference, Adaptive Propagation, and AI-Enabled Mechanistic Insight.International journal of molecular sciences · 2026Review
- Simultaneous encoding of sensory features: the role of multiplexing and noise in tactile perception and neural representation.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Editorial: Advancements in neural coding: sensory perception and multiplexed encoding strategies.Frontiers in computational neuroscience · 2026Article
- Properties of Heterochannels Kv(1.1-1.2)International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons and their subcellular compartments exhibit distinct forms of excitability. In 1948, Alan Hodgkin described different classes of neuronal excitability, each characterized by unique spiking responses to a constant stimulus. Despite these early insights, the mechanisms by which membrane properties influence spike initiation and excitability remain poorly understood. This review explores the nonlinear dynamics underlying spike initiation across excitability classes, emphasizing how these differences contribute to the neural encoding and processing of diverse information. Within a single neuron, compartments such as the soma, axon initial segment (AIS), and axon can exhibit functionally distinct excitability profiles due to differences in ion channel expression and membrane properties. For instance, the biophysical properties of myelinated axons, particularly the expression and distribution of voltage-gated potassium (Kv1) channels, play a key role in maintaining the directional fidelity of action potential propagation by facilitating orthodromic transmission and suppressing antidromic activity. These compartment-specific dynamics underscore the intricate design of neural systems to maintain the precision and efficiency of neural signalling. Moreover, perturbations in excitability are implicated in various neurological disorders, including epilepsy and chronic pain, highlighting the importance of maintaining physiological excitability profiles. By exploring these mechanisms, this review aims to provide insight into how alterations in membrane biophysics may inform future therapeutic strategies targeting excitability-related pathologies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.