Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Bing LiuMarshall Laboratory of Biomedical Engineering，Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.ORCID http://orcid.org/0000-0002-1294-4805
Letong CaiMarshall Laboratory of Biomedical Engineering，Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.ORCID http://orcid.org/0009-0007-6969-7298
Yiwen YanMarshall Laboratory of Biomedical Engineering，Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.ORCID http://orcid.org/0009-0006-3522-5260
Chengzhou MaoMarshall Laboratory of Biomedical Engineering，Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.ORCID http://orcid.org/0009-0007-1423-6929
Xiaohui ZhangMarshall Laboratory of Biomedical Engineering，Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.
Yudan HeMarshall Laboratory of Biomedical Engineering，Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.ORCID http://orcid.org/0009-0000-9067-8429
Si ChenMarshall Laboratory of Biomedical Engineering，Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.ORCID http://orcid.org/0000-0002-3820-1065
Lizhong LiuMarshall Laboratory of Biomedical Engineering，Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.ORCID http://orcid.org/0000-0003-4751-1679
Zhe XuDepartment of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.ORCID http://orcid.org/0000-0002-3338-4229
Long XuDepartment of Gastroenterology and Hepatology, Shenzhen University General Hospital, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.ORCID http://orcid.org/0000-0003-2869-8474
FuSheng WangDepartment of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.ORCID http://orcid.org/0000-0002-8043-6685
Li YuDepartment of Hematology and Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.
A H Jan DanserDivision of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus Medical Center, Rotterdam University, Rotterdam, Netherlands.
Xifeng LuDepartment of Pharmacology, Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University Medical College, Shantou University, Shantou, Guangdong, China shaojun-xing@szu.edu.cn xifenglu@stu.edu.cn.ORCID http://orcid.org/0000-0002-4782-0300
Shaojun XingMarshall Laboratory of Biomedical Engineering，Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China shaojun-xing@szu.edu.cn xifenglu@stu.edu.cn.ORCID http://orcid.org/0000-0003-0777-2196
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
backgroundTumor-derived proprotein convertase subtilisin/kexin type 9 (PCSK9) facilitates tumor progression, but the role of immune cell-intrinsic PCSK9 in tumor control remains unclear.
methodsOrthotopic models of pancreatic cancer and melanoma in
resultsAblation of host Pcsk9 remarkably suppressed tumor growth and prolonged the survival of tumor-bearing mice, while tumor cells still express PCSK9. The enhanced tumor suppression in
conclusionThese findings indicate that PCSK9 inhibits the antitumor function of CD8
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Disruption of cell-intrinsic PCSK9 enhances the antitumor efficacy of CD8 · full record | Socratic