Evidence map›Paper›PMID 40664633›Full record

ArticleNature communications2025

Activated GDF11/8 subforms predict cardiovascular events and mortality in humans.

Ryan G Walker, Tomohiro Kato, Laura Ben Driss, Stephen A Williams, Michael A Hinterberg, Nebojsa Janjic, Amy D Gelinas, Meredith A Carpenter, Chandramohan Kattamuri, Joan E Walter and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ryan G Walker *Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
Tomohiro Kato *Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
Laura Ben DrissDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9633-7537
Stephen A WilliamsSomaLogic Inc, Boulder, CO, USA.ORCID http://orcid.org/0000-0002-8661-4315
Michael A HinterbergSomaLogic Inc, Boulder, CO, USA.
Nebojsa JanjicSomaLogic Inc, Boulder, CO, USA.ORCID http://orcid.org/0000-0001-6811-167X
Amy D GelinasSomaLogic Inc, Boulder, CO, USA.
Meredith A CarpenterSomaLogic Inc, Boulder, CO, USA.
Chandramohan KattamuriDepartment of Molecular & Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Joan E WalterDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Christian MuellerDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1120-6405
Kourtney R MendelloDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
Justis V GordonDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
Keenan A WalkerLaboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5989-9853
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4598-0669
Shalender BhasinResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lee L RubinDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8658-841X
Amy J WagersDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
Thomas B ThompsonDepartment of Molecular & Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Peter GanzDivision of Cardiology, Zuckerberg San Francisco General Hospital and Department of Medicine, University of California, San Francisco, CA, USA. peter.ganz@ucsf.edu.ORCID http://orcid.org/0000-0002-0437-8882
Richard T LeeDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. richard_lee@harvard.edu.ORCID http://orcid.org/0000-0003-4687-1381

Funding

TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEWIS LIPSITZ · 2008 to 2026
$23.9M
MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Elucidating the Biology of Cardiovascular Risk in Hemodialysis Patients Using ProteomicsR01HL153499 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI DUBIN, RUTH, GANZ, PETER · 2021 to 2024
$3.4M
Direct and Indirect Effects of GDF11 in the Aging Central Nervous SystemR01AG072086 · NIA · HARVARD UNIVERSITY · PI RUBIN, LEE L · 2020 to 2024
$3.1M
Regulation of GDF11 by extracellular mechanismsR01AG072087 · NIA · UNIVERSITY OF CINCINNATI · PI THOMPSON, THOMAS B · 2020 to 2024
$2.8M
Structural/functional characterization of TGFβ superfamily signaling and regulationR35GM134923 · NIGMS · UNIVERSITY OF CINCINNATI · PI THOMPSON, THOMAS B · 2020 to 2024
$2.6M
Myocardial Physiology of Growth Differentiation Factor SignalingR01HL169291 · NHLBI · HARVARD UNIVERSITY · PI RICHARD T LEE · 2023 to 2026
$2.4M
Investigating GDF11 and MSTN as candidate circulating geronic factorsR01AG057428 · NIA · HARVARD UNIVERSITY · PI WAGERS, AMY JO · 2017 to 2020
$2.0M
A New Pathway for Reversing Cardiac AgingR01AG047131 · NIA · HARVARD UNIVERSITY · PI LEE, RICHARD T · 2015 to 2019
$1.7M
Anti-Geronic Factors, GDF11 and Oxytocin, and Aging-Related PhenotypesR56AG052972 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BHASIN, SHALENDER · 2016 to 2017
$353k
In vivo Structure-Function relationships of GDF11 and GDF8R56AG062468 · NIA · HARVARD UNIVERSITY · PI LEE, RICHARD T · 2020 to 2020
$346k
NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL153499NHLBI NIH HHS R01 HL169291NHLBI NIH HHS T32 HL007208NIA NIH HHS P30 AG031679NIA NIH HHS R01 AG047131NIA NIH HHS R01 AG057428NIA NIH HHS R01 AG072086NIA NIH HHS R01 AG072087NIA NIH HHS R56 AG052972NIA NIH HHS R56 AG062468NIGMS NIH HHS R35 GM134923U.S. Department of Health & Human Services | National Institutes of Health (NIH) 4T32HL007208U.S. Department of Health & Human Services | National Institutes of Health (NIH) HL169291U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG047131U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) 1R56AG052972U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) P30AG31679U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) R01AG072086U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) R01AG072087U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) R01HL059367U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) R01HL153499-02U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) R35GM134923
6 · The paper itself

Abstract

Circulating Growth Differentiation Factors 11 and 8 (GDF11/8) exist in both latent and active forms, and it is unclear if specific forms can predict disease outcomes. Our data suggest that a dual-specific aptamer selectively binds GDF11/8 after prodomain activation. In 11,609 patients at risk for future cardiovascular events, low dual-specific aptamer-detected GDF11/8 levels strongly predicted adverse outcomes, including cardiovascular events (HR = 0.43, p = 9.1 × 10⁻⁶³) and all-cause mortality (HR = 0.33, p = 4.8 × 10⁻⁴⁰). Use of selective aptamers suggested that results observed with the dual-specific aptamer for cardiovascular and mortality risk replicated with a GDF8 aptamer although with a smaller effect size. In a second cohort of 4110 individuals (ARIC), low dual-specific aptamer-detected GDF11/8 levels also predicted increased 8 year dementia risk (HR = 0.66, p = 0.00148). Our findings reveal that activation of GDF11/8 may be a factor in future aging-related cardiovascular and cognitive decline.

Indexed as

Bone Morphogenetic ProteinsCardiovascular DiseasesGrowth Differentiation FactorsMyostatinAgedAptamers, NucleotideBiomarkersFemaleHumansMaleMiddle AgedRisk FactorsAptamers, NucleotideBiomarkersBone Morphogenetic ProteinsGDF11 protein, humanGrowth Differentiation FactorsMSTN protein, humanMyostatin

Identifiers

PMID40664633
PMCPMC12263990

What Socratic holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.