Evidence map›Paper›PMID 40664658›Full record

ArticleNature communications2025

Pregnancy-acquired memory CD4

Kristin Thiele, Christopher Urbschat, Julia Isabel Amambay Riquelme, Lisa Sophie Ahrendt, Ronja Wöhrle, Steven Schepanski, Judith Joana Eckert, Etienne Becht, Minyue Qi, Malik Alawi and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Resolving ScRNA-Seq Signatures of Antigen-Specific CD4bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kristin ThieleDivision of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. k.thiele@uke.de.ORCID http://orcid.org/0000-0002-9343-9834
Christopher UrbschatDivision of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-8866-9133
Julia Isabel Amambay RiquelmeDivision of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lisa Sophie AhrendtDivision of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ronja WöhrleDivision of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Steven SchepanskiDivision of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7695-1289
Judith Joana EckertDivision of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Etienne BechtVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, USA.ORCID http://orcid.org/0000-0003-1859-9202
Minyue QiBioinformatics Core, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0003-4823-3439
Malik AlawiBioinformatics Core, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-5993-7709
Martin BeckerChair for Intelligent Data Analytics, Institute for Visual and Analytic Computing, Department of Computer Science and Electrical Engineering, University of Rostock, Rostock, Germany.ORCID http://orcid.org/0000-0003-4296-3481
Nicola GaglianiHamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-8514-1395
Hans-Willi MittrückerInstitute for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-6166-4191
Anke DiemertDepartment of Obstetrics and Fetal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Petra Clara ArckDivision of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. p.arck@uke.de.ORCID http://orcid.org/0000-0002-2932-926X

Funding

cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01GL2404ADeutsche Forschungsgemeinschaft (German Research Foundation) AR232/26-2, AR232/27-2, AR232/29-2Deutsche Forschungsgemeinschaft (German Research Foundation) Scholarship from the IRTG of the CRC1192Deutsche Forschungsgemeinschaft (German Research Foundation) TH 2126/1-1Else Kröner-Fresenius-Stiftung (Else Kroner-Fresenius Foundation) iPRIME ScholarshipNHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIDA NIH HHS 75N95020D00005ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

Subsequent pregnancies are generally less prone to obstetric complications. A successful pregnancy outcome requires pivotal immunological adaptation to ensure immune tolerance towards the foetus. Thus, the lower risk for pregnancy complication during subsequent pregnancies may be attributable to immune memory mounted during first pregnancies. Here we identify higher frequencies of fetal-antigen-specific CD4

Indexed as

Immunologic MemoryPregnancy OutcomeT-Lymphocytes, RegulatoryAnimalsFemaleMiceMice, Inbred C57BLPregnancyReceptors, CXCR4Th17 CellsCXCR4 protein, mouseReceptors, CXCR4

Identifiers

PMID40664658
PMCPMC12263984

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.