Evidence map›Paper›PMID 40664676›Full record

GuidelineInternational journal of oral science2025

Expert consensus on the prevention and treatment of radiochemotherapy-induced oral mucositis.

Juan Xia, Xiaoan Tao, Qinchao Hu, Wei Luo, Xiuzhen Tong, Gang Zhou, Hongmei Zhou, Hong Hua, Guoyao Tang, Tong Wu and 22 more

Abstract readConsensus StatementPractice Guideline
In one paragraph

Guideline in International journal of oral science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Efficacy of acupuncture in managing radiotherapy/chemotherapy-induced oral mucositis: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  3. Trial
  4. Cancer pain.Nature reviews. Disease primers · 2026
    Review
  5. Article
  6. Observational
  7. Review
  8. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Recombinant Molecules as a New Frontier in Mucositis Therapy.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Juan Xia *Department of Oral Medicine, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
Xiaoan Tao *Department of Oral Medicine, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
Qinchao Hu *Department of Oral Medicine, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
Wei LuoDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xiuzhen TongDepartment of Hematology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Gang ZhouDepartment of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Hongmei ZhouState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Hong HuaDepartment of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China.
Guoyao TangDepartment of Stomatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tong WuDepartment of Oral Medicine, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.ORCID 0000-0001-7455-9083
Qianming ChenState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.ORCID 0000-0002-5371-4432
Yuan FanDepartment of Oral Medicine, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Xiaobing GuanBeijing Stomatological Hospital, Capital Medical University, Beijing, China.
Hongwei LiuDepartment of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China.
Chaosu HuDepartment of Radiation Oncology, Fudan University Shanghai Cancer Centre, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Yongmei ZhouDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuemin ShenDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lan WuDepartment of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xin ZengState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Qing LiuThe Third Affiliated Hospital of Air Force Medical University, Xi'an, China.
Renchuan TaoDepartment of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, Nanning, China.
Yuan HeShanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Oral Medicine, School of Stomatology, Tongji University, Shanghai, China.
Yang CaiHospital and School of Stomatology, Guizhou Medical University, Guiyang, China.
Wenmei WangDepartment of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
Ying ZhangDepartment of Oral Emergency and Mucosal Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, China.
Yingfang WuCentre of Stomatology, Xiangya Hospital, Cental South University, Changsha, China.
Minhai NieDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical University, Luzhou, China.
Xin JinChongqing Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing, China.
Xiufeng WeiSchool of Stomatology, Jilin University, Changchun, China.
Yongzhan NieState Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.ORCID 0000-0003-1124-4548
Changqing YuanDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Bin ChengDepartment of Oral Medicine, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China. chengbin@mail.sysu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) U23A20445
6 · The paper itself

Abstract

Radiochemotherapy-induced oral mucositis (OM) is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy. Erosion and ulcers are the main features of OM that seriously affect the quality of life of patients and even the progress of tumor treatment. To date, differences in clinical prevention and treatment plans for OM have been noted among doctors of various specialties, which has increased the uncertainty of treatment effects. On the basis of current research evidence, this expert consensus outlines risk factors, clinical manifestations, clinical grading, ancillary examinations, diagnostic basis, prevention and treatment strategies and efficacy indicators for OM. In addition to strategies such as basic oral care, anti-inflammatory and analgesic agents, anti-infective agents, pro-healing agents, and photobiotherapy recommended in previous guidelines, we also emphasize the role of traditional Chinese medicine in OM prevention and treatment. This expert consensus aims to provide references and guidance for dental physicians and oncologists in formulating strategies for OM prevention, diagnosis, and treatment, standardizing clinical practice, reducing OM occurrence, promoting healing, and improving the quality of life of patients.

Indexed as

ChemoradiotherapyStomatitisHumansRisk Factors

Identifiers

PMID40664676
PMCPMC12264017

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.