Evidence map›Paper›PMID 40664708›Full record

ArticleScientific reports2025

Leptin signaling in POMC neurons regulates plasma leptin levels and is critical to mediate hypothalamic-pituitary-adrenal axis activation during fasting.

Nathalia Lopes Ferreira, Higor J Fideles, Ana Beatriz Marcal, Ana Paula Brianezi, João Victor Silva Nani, André Souza Mecawi, Rodrigo Rorato

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nathalia Lopes FerreiraLaboratory of Stress Neuroendocrinology, Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo, Sao Paulo, SP, 04023- 062, Brazil.
Higor J FidelesLaboratory of Stress Neuroendocrinology, Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo, Sao Paulo, SP, 04023- 062, Brazil.
Ana Beatriz MarcalLaboratory of Stress Neuroendocrinology, Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo, Sao Paulo, SP, 04023- 062, Brazil.
Ana Paula BrianeziLaboratory of Stress Neuroendocrinology, Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo, Sao Paulo, SP, 04023- 062, Brazil.
João Victor Silva NaniLaboratory of Molecular Neuroendocrinology, Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo, Sao Paulo, 04023- 062, Brazil.
André Souza MecawiLaboratory of Molecular Neuroendocrinology, Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo, Sao Paulo, 04023- 062, Brazil.
Rodrigo RoratoLaboratory of Stress Neuroendocrinology, Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo, Sao Paulo, SP, 04023- 062, Brazil. rorato@unifesp.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 131367/2021-8Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.684167/2022-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/17968-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/27581-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/12478-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/12497-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/15733-8
6 · The paper itself

Abstract

The reduction in plasma leptin levels is crucial for the brain to perceive negative energy balance and activate adaptive responses, including activating corticotrophin-releasing factor neurons in the paraventricular nucleus of the hypothalamus (CRF

Indexed as

FastingHypothalamo-Hypophyseal SystemLeptinNeuronsPituitary-Adrenal SystemPro-OpiomelanocortinSignal TransductionAgouti-Related ProteinAnimalsCorticosteroneMaleMiceMice, Inbred C57BLParaventricular Hypothalamic NucleusReceptors, LeptinAgouti-Related ProteinCorticosteroneLeptinleptin receptor, mousePro-OpiomelanocortinReceptors, LeptinCre-LoxPDREADDsFastingHPA axisLeprPOMC

Identifiers

PMID40664708
PMCPMC12263973

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.