Evidence map›Paper›PMID 40664815›Full record

ArticleNPJ digital medicine2025

Transdiagnostic-focused apps for depression and anxiety: a meta-analysis.

Jake Linardon, Cleo Anderson, Mariel Messer, Claudia Liu, John Torous

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Reducing the 'Silence Between Sessions': A Qualitative Study on Youth and Professionals' Perspectives on Digital Tools for Suicide Prevention.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  7. Framing Helper Therapy to Support User Engagement: Causal Evidence from a Public Deployment of a Mental Health Support Text Messaging Program.Proceedings of the SIGCHI conference on human factors in computing systems. CHI Conference · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jake LinardonSEED Lifespan Strategic Research Centre, School of Psychology, Faculty of Health, Deakin University, Geelong, VIC, Australia. Jake.Linardon@deakin.edu.au.ORCID http://orcid.org/0000-0003-4475-7139
Cleo AndersonSEED Lifespan Strategic Research Centre, School of Psychology, Faculty of Health, Deakin University, Geelong, VIC, Australia.
Mariel MesserSEED Lifespan Strategic Research Centre, School of Psychology, Faculty of Health, Deakin University, Geelong, VIC, Australia.
Claudia LiuSEED Lifespan Strategic Research Centre, School of Psychology, Faculty of Health, Deakin University, Geelong, VIC, Australia.
John TorousDivision of Digital Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mental health apps that adopt a transdiagnostic approach to addressing depression and anxiety are emerging, yet a synthesis of their evidence-base is missing. This meta-analysis evaluated the efficacy of transdiagnostic-focused apps for depression and anxiety, and aimed to understand how they compare to diagnostic-specific apps. Nineteen randomized controlled trials (N = 5165) were included. Transdiagnostic-focused apps produced small post-intervention effects relative to controls on pooled outcomes related depression, anxiety and distress (N = 23 comparisons; g = 0.29; 95% CI = 0.17-0.40). Effects remained significant across various sensitivity analyses. CBT apps and apps that were compared with a waitlist produced larger effects. Significant effects were found at follow-up (g = 0.25; 95% CI = 0.10, 0.41). Effects were comparable to disorder-specific app estimates. Findings highlight the potential of transdiagnostic apps to provide accessible support for managing depression and anxiety. Their broad applicability highlights their public health relevance, especially when combined with in-person transdiagnostic therapies to create new hybrid care models.

Identifiers

PMID40664815
PMCPMC12264056

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.